Breast cancer risk with postmenopausal hormonal treatment

John A. Collins, Jennifer M. Blake, Pier Giorgio Crosignani

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

This review was designed to determine from the best evidence whether there is an association between postmenopausal hormonal treatment and breast cancer risk. Also, if there is an association, does it vary according to duration and cessation of use, type of regimen, type of hormonal product or route of administration; whether there is a differential effect on risk of lobular and ductal cancer; and whether hormone treatment is associated with breast cancers that have better prognostic factors? Data sources for the review included Medline, the Cochrane Database of Systematic Reviews (Cochrane Library, 2005) and reference lists in the identified citations. Eligible citations addressed invasive breast cancer risk among postmenopausal women and involved use of the estrogen products with or without progestin that are used as treatment for menopausal symptoms. Abstracted data were demographic groupings, categories of hormone use, categories of breast cancer, two-by-two tables of exposure and outcome and adjusted odds ratios, relative risks (RRs) or hazard rates. Average estimates of risk were weighted by the inverse variance method, or if heterogeneous, using a random effects model. The average risk of invasive breast cancer with estrogen use was 0.79 [95% confidence interval (95% CI) = 0.61-1.02] in four randomized trials involving 12 643 women. The average breast cancer risk with estrogen-progestin use was 1.24 (95% CI = 1.03-1.50) in four randomized trials involving 19 756 women. The average risks reported in recent epidemiological studies were higher: 1.18 (95% CI = 1.01-1.38) with current use of estrogen alone and 1.70 (95% CI = 1.36-2.17) with current use of estrogen-progestin. The association of breast cancer with current use was stronger than the association with ever use, which includes past use. For past use, the increased breast cancer risk diminished soon after discontinuing hormones and normalized within 5 years. Reasonably adequate data do not show that breast cancer risk varies significantly with different types of estrogen or progestin preparations, lower dosages or different routes of administration, although there is a small difference between sequential and continuous progestin regimens. Epidemiological studies indicate that estrogen-progestin use increases risk of lobular more than ductal breast cancer, but the number of studies and cases of lobular cancer remains limited. Among important prognostic factors, the stage and grade in breast cancers associated with hormone do not differ significantly from those in non-users, but breast cancers in estrogen-progestin users are significantly more likely to be estrogen receptor (ER) positive. In conclusion, valid evidence from randomized controlled trials (RCTs) indicates that breast cancer risk is increased with estrogen-progestin use more than with estrogen alone. Epidemiological evidence involving more than 1.5 million women agrees broadly with the trial findings. Although new studies are unlikely to alter the key findings about overall breast cancer risk, research is needed, however, to determine the role of progestin, evaluate the risk of lobular cancer and delineate effects of hormone use on receptor presence, prognosis and mortality in breast cancer.

Original languageEnglish
Pages (from-to)545-560
Number of pages16
JournalHuman Reproduction Update
Volume11
Issue number6
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Breast Neoplasms
Progestins
Estrogens
Therapeutics
Hormones
Confidence Intervals
Epidemiologic Studies
Neoplasms
Information Storage and Retrieval
Estrogen Receptors
Libraries
Randomized Controlled Trials
Odds Ratio
Demography
Databases
Mortality

Keywords

  • Breast cancer
  • Duration of use
  • Estrogen
  • Progestin
  • Recency
  • Relative risk

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine

Cite this

Breast cancer risk with postmenopausal hormonal treatment. / Collins, John A.; Blake, Jennifer M.; Crosignani, Pier Giorgio.

In: Human Reproduction Update, Vol. 11, No. 6, 11.2005, p. 545-560.

Research output: Contribution to journalArticle

Collins, JA, Blake, JM & Crosignani, PG 2005, 'Breast cancer risk with postmenopausal hormonal treatment', Human Reproduction Update, vol. 11, no. 6, pp. 545-560. https://doi.org/10.1093/humupd/dmi028
Collins, John A. ; Blake, Jennifer M. ; Crosignani, Pier Giorgio. / Breast cancer risk with postmenopausal hormonal treatment. In: Human Reproduction Update. 2005 ; Vol. 11, No. 6. pp. 545-560.
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