Abstract
Normal adult tissue stem cells awake from a dormant state to grow, differentiate, and regenerate damaged tissue. They also travel in the circulation and colonize distant organs at sites undergoing tissue repair. These same traits are utilized or co-opted by metastatic cancer cells. The cancer stem cell theory proposes that tumors emerge from a subpopulation of cancer cells that possess stem cell properties. This theory has profound implications for therapy. A small number of cancer stem cells may lie dormant following conventional therapy and tumor remission, only to re-emerge and regenerate the entire recurrent cancer. Consequently, it has been proposed that targeting cancer stem cells is the only way to obtain durable cancer treatment responses. Several strategies for targeting cancer stem cells have been proposed. Nevertheless, a number of issues must be investigated and resolved before effective treatments targeting cancer stem cells can enter clinical testing.
| Original language | English |
|---|---|
| Journal | Oncology |
| Volume | 25 |
| Issue number | 1 |
| Publication status | Published - Jan 2011 |
Fingerprint
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Breast cancer stem cells : A new target for therapy. / Federici, Giulia; Espina, Virginia; Liotta, Lance; Edmiston, Kirsten H.
In: Oncology, Vol. 25, No. 1, 01.2011.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast cancer stem cells
T2 - A new target for therapy
AU - Federici, Giulia
AU - Espina, Virginia
AU - Liotta, Lance
AU - Edmiston, Kirsten H.
PY - 2011/1
Y1 - 2011/1
N2 - Normal adult tissue stem cells awake from a dormant state to grow, differentiate, and regenerate damaged tissue. They also travel in the circulation and colonize distant organs at sites undergoing tissue repair. These same traits are utilized or co-opted by metastatic cancer cells. The cancer stem cell theory proposes that tumors emerge from a subpopulation of cancer cells that possess stem cell properties. This theory has profound implications for therapy. A small number of cancer stem cells may lie dormant following conventional therapy and tumor remission, only to re-emerge and regenerate the entire recurrent cancer. Consequently, it has been proposed that targeting cancer stem cells is the only way to obtain durable cancer treatment responses. Several strategies for targeting cancer stem cells have been proposed. Nevertheless, a number of issues must be investigated and resolved before effective treatments targeting cancer stem cells can enter clinical testing.
AB - Normal adult tissue stem cells awake from a dormant state to grow, differentiate, and regenerate damaged tissue. They also travel in the circulation and colonize distant organs at sites undergoing tissue repair. These same traits are utilized or co-opted by metastatic cancer cells. The cancer stem cell theory proposes that tumors emerge from a subpopulation of cancer cells that possess stem cell properties. This theory has profound implications for therapy. A small number of cancer stem cells may lie dormant following conventional therapy and tumor remission, only to re-emerge and regenerate the entire recurrent cancer. Consequently, it has been proposed that targeting cancer stem cells is the only way to obtain durable cancer treatment responses. Several strategies for targeting cancer stem cells have been proposed. Nevertheless, a number of issues must be investigated and resolved before effective treatments targeting cancer stem cells can enter clinical testing.
UR - http://www.scopus.com/inward/record.url?scp=79551709320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79551709320&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:79551709320
VL - 25
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 1
ER -