Breast cancer stem cells: An overview

Dario Ponti, Nadia Zaffaroni, Chiara Capelli, Maria Grazia Daidone

Research output: Contribution to journalArticle

Abstract

The theory that cancer may be originated and sustained by a small proportion of stem-like, self-renewing cells (termed 'cancer stem cells') has gained support in recent years. Breast cancer stem cells have been identified as CD44+CD24- breast tumour cells and have recently been isolated and propagated in vitro. It has been demonstrated that these cells exclusively retain the ability to form new tumours in mouse models and that they display stem/progenitor cell properties. The ability to identify breast cancer stem cells in vivo and to propagate them in vitro provides the means to compare them with normal cells, in order to investigate from which cell they originate, which molecular alterations critically affect them, and how they interact with the microenvironment. Elucidation of these critical points is essential to develop new therapeutic strategies and to improve diagnosis and prognosis for breast cancer patients.

Original languageEnglish
Pages (from-to)1219-1224
Number of pages6
JournalEuropean Journal of Cancer
Volume42
Issue number9
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Breast cancer
  • Breast cancer stem cells
  • Breast cancer-initiating cells
  • In vitro propagation
  • Isolation of breast cancer stem cells
  • Mammary stem cells
  • Mammospheres

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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