Breast carcinoma during pregnancy: International recommendations from an expert meeting

Sibylle Loibl, Gunter Von Minckwitz, Karin Gwyn, Paul Ellis, Jens U. Blohmer, Brigitte Schlegelberger, Monika Keller, Sebastian Harder, Richard L. Theriault, Diana Crivellari, Thomas Klingebiel, Frank Louwen, Manfred Kaufmann

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Breast carcinoma during pregnancy (BCP) is a difficult clinical situation, as it appears to put the health of the mother in conflict with that of the fetus. METHODS. An international expert meeting was conducted to form guidelines on how to diagnose and treat women with BCP. RESULTS. The goal for treatment of the pregnant woman with breast carcinoma is the same as that of the nonpregnant breast carcinoma patient: local control of disease and prevention of systemic metastases. However, certain treatment modalities need to be modified because of the potential for adverse effects on the fetus. There is evidence to support the safety of anthracycline-based chemotherapy during the second and third trimesters of pregnancy (Oxford Level of Evidence [LOE] 2b). Because of the lack of evidence, the expert opinion was not to recommend the routine use of newer cytotoxic drugs like the taxanes during pregnancy (LOE 5). CONCLUSION. The recommendations provided should help to reach informed decision making by the patient. The ongoing prospective collection of data on BCP, such as that at the University of Texas M.D. Anderson Cancer Center (UTMDACC) and that of the German Breast Group/Breast International Group (GBG/BIG), is necessary to further our knowledge regarding the treatment of this unique group of breast carcinoma patients.

Original languageEnglish
Pages (from-to)237-246
Number of pages10
JournalCancer
Volume106
Issue number2
DOIs
Publication statusPublished - Jan 15 2006

Keywords

  • Breast carcinoma
  • Chemotherapy
  • Pregnancy
  • Recommendation

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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