Breast conserving treatment for ductal carcinoma in situ in the elderly: Can radiation therapy be avoided? Our experience

Giuseppe Falco, Nicola Rocco, Eugenio Procaccini, Maria Giulia Sommella, Daniele Bordoni, Eugenio Cenini, Fabio Castagnetti, Vincenzo Sabatino, Rita Compagna, Gianni Antonio Della Corte, Antonello Accurso, Bruno Amato, Guglielmo Ferrari

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: Ductal Carcinoma In Situ (DCIS) is a heterogeneous, pre-malignant disease accounting for 15-20% of all new breast cancers. If appropriately managed, DCIS has a small chance of impacting on patient life expectancy. Despite the possibility of a further recurrence or of a development in an invasive form, we are unable to select treatment of choice especially in the elderly. In particularly we risk an overtreatment of women at low risk of progression to invasive breast cancer. The aim of this study was to retrospectively evaluate the outcome of elderly patients affected by DCIS not undergoing Radiation Therapy (RT) after Breast Conserving Surgery (BCS). Material and methods: We reviewed our prospectively-maintained database from 1998 to 2013, selecting all women over 65 years old diagnosed with DCIS who did not receive RT for personal choice. We considered two groups, according to the risk of local recurrence (Low Risk (Group 1) vs. High Risk (Group 2)). Results: We identified 44 cases of DCIS treated with surgery alone or with surgery followed by adjuvant tamoxifen. 24 patients presented low risk of local recurrence (Group 1) and 20 had characteristics associated to high risk of local recurrence (Group 2). At a median follow-up of 66.3 months, no local recurrences have been described in group 1. No patients presented distant metastases, while 4 patients died for other causes. At a median follow-up of 72 months we observed 5 local recurrences in the second group (p

Original languageEnglish
Pages (from-to)S47-S49
JournalInternational Journal of Surgery
Volume12
Issue numberS2
DOIs
Publication statusPublished - Oct 1 2014

Keywords

  • Breast cancer
  • Breast conserving treatment
  • Ductal carcinoma in situ
  • Radiation therapy

ASJC Scopus subject areas

  • Surgery
  • Medicine(all)

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