Breast fine-needle aspiration malondialdehyde deoxyguanosine adduct in breast cancer

Marco Peluso, Armelle Munnia, Gabriella G. Risso, Sandra Catarzi, Sara Piro, Marcello Ceppi, Roger W. Giese, Beniamino Brancato

Research output: Contribution to journalArticlepeer-review

Abstract

This study has analysed the generation of 3-(2-deoxy-β-D-erythro- pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine adduct [M1dG], a biomarker of oxidative stress and lipid peroxidation, in breast fine-needle aspirate samples of 22 patients with breast cancer, at different clinical stages, in respect to 13 controls. The multivariate analysis show that M 1dG adduct was higher in cases than in controls (Mean Ratio (MR) = 5.26, 95% CI = 3.168.77). Increased M 1dG was observed in women with a tumour grade 3 and a pathological diameter 2 (MR = 7.61, 95% CI = 3.9114.80 and MR = 5.75, 95% CI = 3.1310.59, respectively). A trend with increasing tumour grade and pathological diameter was present (MR = 1.98, 95% CI = 1.572.50 and MR = 2.44, 95% CI = 1.713.48, respectively). Not significant effects of age and smoking habit were found (MR = 1.58, 95% CI = 0.922.72 and MR = 1.68, 95% CI 0.883.20, respectively). An increment over the background frequency of M 1dG can contribute to breast cancer development. Increasing severity of breast tumour can influence DNA damage level.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalFree Radical Research
Volume45
Issue number4
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Breast cancer
  • fi ne-needle aspirate
  • free radicals
  • M dG
  • pathological diameter
  • tumour grade

ASJC Scopus subject areas

  • Biochemistry

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