Breast intraductal masses: US-guided fine-needle aspiration after galactography

Francesco Sardanelli, Andrea Imperiale, Franco Zandrino, Massimo Calabrese, Antonino Bonifacio, Giuseppe Canavese, Guido Nicolò

Research output: Contribution to journalArticlepeer-review


PURPOSE: To evaluate ultrasonographic (US)-guided fine-needle aspiration (FNA) of intraductal masses performed immediately after galactography and to compare cytologic findings from US-guided FNA with those from nipple discharge. MATERIALS AND METHODS: In 36 patients with nipple discharge from a single duct in one breast and intraductal masses diagnosed at galactography, US was performed to detect intraductal lesions and perform FNA before removal of the galactographic catheter. Cytologic analysis of nipple discharge, excisional biopsy, and histopathologic evaluation were per formed in ill patients. RESULTS: Cytologic analysis revealed 23 nonpapillary benignancies, seven papillomas, five indeterminate cases, and one carcinoma. US-guided FNA cytologic analysis revealed 16 papillomas, 10 nonpapillary benign-uncles, five indeterminate cases, and three carcinomas. The two carcinomas misdiagnosed as papillomas at US-guided FNA cytologic analysis were papillary in situ carcinomas, while the three carcinomas correctly identified were invasive (only one was detected with cytologic analysis of nipple discharge). With cytologic analysis of nipple discharge, nine (25%) of 36 diagnoses were correct, and with US-guided FNA, 18 (50%) were correct (P = .0352). CONCLUSION: Compared with cytologic analysis of nipple discharge, US-guided FNA cytologic analysis seems to add useful information for tailored surgical planning.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
Issue number1
Publication statusPublished - Jul 1997


  • Breast neoplasms, diagnosis
  • Breast, biopsy
  • Galactography
  • Ultrasound (US), guidance

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology


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