Breast irradiation with three conformal photon fields for patients with high lung involvement

Luca Cozzi, Antonella Fogliata, Giorgia Nicolini, Tiziana Rancati, Jacques Bernier

Research output: Contribution to journalArticlepeer-review


Since 2001, 50 breast cancer patients, for whom extensive lung/heart involvement was expected from the use of conventional tangential 2-field technique (2F) owing to complex anatomies, were irradiated using a 3-field conformal technique (3F). Dose plans were designed for both 3F and 2F and a dose volume histogram analysis on ipsilateral lung, heart, and target was conducted. The 3F technique allowed a significant reduction in ipsilateral lung irradiation: mean dose dropped from 16.0 ± 3.8 (2F) to 12.0 ± 2.7 Gy (3F) and V45Gy from 20.7 ± 6.8 (2F) to 3.2 ± 2.9% (3F). Similarly, in patients irradiated to the left breast, heart mean dose was reduced from 8.1 Gy (2F) to 6.8 Gy (3F) and D15% from 19.0 Gy to 14.0 Gy. All differences reached a high degree of significance. The target coverage was not clinically compromised since the slight reduction using 3F compared with 2F is limited to V95% while V90% difference, even if statistically significant, is small: 98.2 ± 1.8% (3F) and 98.8 ± 1.6 (2F). A preliminary report on clinical follow up is also included; with a mean follow up of 15.8 months, no pulmonary or cardiac complications were observed.

Original languageEnglish
Pages (from-to)558-566
Number of pages9
JournalActa Oncologica
Issue number6
Publication statusPublished - 2004

ASJC Scopus subject areas

  • Oncology


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