Breast microcalcifications studied with 3D contrast-enhanced high-field magnetic resonance imaging: More accuracy in the diagnosis of breast cancer

Giovanna Trecate, John David Tesoro Tess, Daniele Vergnaghi, Silvana Bergonzi, Tiziana De Simone, Gabriella Mariani, Renato Musumeci

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: To evaluate the reliability of magnetic resonance imaging (MRI) performed with three-dimensional (3D) sequences in mammographically detected breast microcalcifications. Methods: During an 8-month period, a group of 28 patients with mammographically detected microcalcifications suspicious for malignancy underwent MRI. Their ages ranged from 33 to 65 years. Examinations were performed with a 1.5 Tesla MR unit and a 3D T1 weighted sequence. Images were interpreted on the basis of morphologic parameters and dynamic behavior in the uptake of contrast medium (Gd-DTPA). Histologic findings were considered as the gold reference. Results: Histologic analysis revealed invasive carcinoma in 7 patients, 3 of which were associated with foci of lobular carcinoma in situ. Intraductal carcinoma was diagnosed in 8 patients, 1 of which was associated with a tubular carcinoma. Benign lesions accounted for 13 patients. All the neoplastic conditions showed enhancement on MR images (sensitivity, 100%), whereas early and intense enhancement was noted in 5 of 13 benign lesions (specificity, 61%). The positive predictive value was 75% and negative predictive value, 100%. Conclusions: Although an overlap in the enhancement behavior of malignant and some benign lesions is clearly evident, a careful interpretation of MR images is helpful in detecting and mainly ruling out breast cancer combined with mammographically suspicious microcalcifications.

Original languageEnglish
Pages (from-to)224-233
Number of pages10
JournalTumori
Volume88
Issue number3
Publication statusPublished - 2002

Keywords

  • Breast neoplasms
  • Contrast enhancement
  • Diagnosis
  • Magnetic resonance
  • Microcalcifications
  • Time-intensity dynamic profiles

ASJC Scopus subject areas

  • Cancer Research

Fingerprint Dive into the research topics of 'Breast microcalcifications studied with 3D contrast-enhanced high-field magnetic resonance imaging: More accuracy in the diagnosis of breast cancer'. Together they form a unique fingerprint.

Cite this