Breast MR imaging screening in eight women proved or suspected to be carriers of BRCA1&2 gene mutations

A. Cilotti, M. A. Caligo, G. Cipollini, D. Francesca, C. Marini, M. Moretti, M. Roncella, C. Bartolozzi, G. Bevilacqua

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to evaluate the efficacy of MR imaging for the early detection of breast tumor in women at high genetic risk compared to conventional strategies such as ultrasonography and mammography. This study included 8 women, 5 of which had undergone surgery for breast cancer. BRCA germ line mutations were detected in 7 women, one patient was enrolled for more than 50% probability to be carrier of BRCA mutation. RM imaging screening was negative in 7 patients and strongly indicative of a malignant lesion in one. The gold standard was surgery for the suspicious cases and follow-up with clinical examination and conventional imaging every six months for the others. MR imaging proved itself to be a reliable technique in familial breast cancer high risk women.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalJournal of Experimental and Clinical Cancer Research
Volume21
Issue number3 SUPPL.
Publication statusPublished - Sep 2002

Keywords

  • BRCA1 gene
  • Breast cancer
  • MR imaging screening

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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