Abstract
The relationship between brassiere size, as an indicator of breast size, and breast cancer risk was considered in a case-control study conducted between 1991 and 1994 in six Italian centres. Cases were 2,557 women, below age 75, with histologically confirmed breast cancer, and controls were 2,566 women admitted to hospital for a wide spectrum of acute, non-neoplastic, non-hormone-related diseases. Odds ratios (ORs) of breast cancer and their 95% confidence intervals (CIs) were obtained from multiple logistic regression equations including terms for study centre and age, as well as main breast cancer risk factors. A slight inverse relationship was observed between breast size and the risk of breast cancer, with an OR of 1.37 (95% CI 1.05-1.80) for the smallest brassiere size compared with the largest; the increase in risk disappeared after adjustment for main recognized breast cancer risk factors, with an OR of 1.16 (95% CI 0.87-1.54) for brassiere size ≤ 1 compared with ≤ 5. No significant heterogeneity in risk of breast cancer with breast size was found in strata of age at diagnosis, parity, age at first birth, age at menopause, family history of breast cancer, benign breast disease, ever use of oral contraceptives and/or hormone replacement therapy. Thus, this study, based on a large number of caucasian women, provides conclusive evidence of a lack of appreciable association between breast size and breast cancer risk in this Italian population.
| Original language | English |
|---|---|
| Pages (from-to) | 337-342 |
| Number of pages | 6 |
| Journal | European Journal of Cancer Prevention |
| Volume | 5 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1996 |
Fingerprint
Keywords
- breast neoplasms
- breast size
- case-control studies
- risk factors
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Breast size and breast cancer risk. / Tavani, A.; Pregnolato, A.; La Vecchia, C.; Negri, E.; Favero, A.; Franceschi, S.
In: European Journal of Cancer Prevention, Vol. 5, No. 5, 1996, p. 337-342.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Breast size and breast cancer risk
AU - Tavani, A.
AU - Pregnolato, A.
AU - La Vecchia, C.
AU - Negri, E.
AU - Favero, A.
AU - Franceschi, S.
PY - 1996
Y1 - 1996
N2 - The relationship between brassiere size, as an indicator of breast size, and breast cancer risk was considered in a case-control study conducted between 1991 and 1994 in six Italian centres. Cases were 2,557 women, below age 75, with histologically confirmed breast cancer, and controls were 2,566 women admitted to hospital for a wide spectrum of acute, non-neoplastic, non-hormone-related diseases. Odds ratios (ORs) of breast cancer and their 95% confidence intervals (CIs) were obtained from multiple logistic regression equations including terms for study centre and age, as well as main breast cancer risk factors. A slight inverse relationship was observed between breast size and the risk of breast cancer, with an OR of 1.37 (95% CI 1.05-1.80) for the smallest brassiere size compared with the largest; the increase in risk disappeared after adjustment for main recognized breast cancer risk factors, with an OR of 1.16 (95% CI 0.87-1.54) for brassiere size ≤ 1 compared with ≤ 5. No significant heterogeneity in risk of breast cancer with breast size was found in strata of age at diagnosis, parity, age at first birth, age at menopause, family history of breast cancer, benign breast disease, ever use of oral contraceptives and/or hormone replacement therapy. Thus, this study, based on a large number of caucasian women, provides conclusive evidence of a lack of appreciable association between breast size and breast cancer risk in this Italian population.
AB - The relationship between brassiere size, as an indicator of breast size, and breast cancer risk was considered in a case-control study conducted between 1991 and 1994 in six Italian centres. Cases were 2,557 women, below age 75, with histologically confirmed breast cancer, and controls were 2,566 women admitted to hospital for a wide spectrum of acute, non-neoplastic, non-hormone-related diseases. Odds ratios (ORs) of breast cancer and their 95% confidence intervals (CIs) were obtained from multiple logistic regression equations including terms for study centre and age, as well as main breast cancer risk factors. A slight inverse relationship was observed between breast size and the risk of breast cancer, with an OR of 1.37 (95% CI 1.05-1.80) for the smallest brassiere size compared with the largest; the increase in risk disappeared after adjustment for main recognized breast cancer risk factors, with an OR of 1.16 (95% CI 0.87-1.54) for brassiere size ≤ 1 compared with ≤ 5. No significant heterogeneity in risk of breast cancer with breast size was found in strata of age at diagnosis, parity, age at first birth, age at menopause, family history of breast cancer, benign breast disease, ever use of oral contraceptives and/or hormone replacement therapy. Thus, this study, based on a large number of caucasian women, provides conclusive evidence of a lack of appreciable association between breast size and breast cancer risk in this Italian population.
KW - breast neoplasms
KW - breast size
KW - case-control studies
KW - risk factors
UR - http://www.scopus.com/inward/record.url?scp=0030458484&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030458484&partnerID=8YFLogxK
U2 - 10.1097/00008469-199610000-00005
DO - 10.1097/00008469-199610000-00005
M3 - Article
C2 - 8972252
AN - SCOPUS:0030458484
VL - 5
SP - 337
EP - 342
JO - European Journal of Cancer Prevention
JF - European Journal of Cancer Prevention
SN - 0959-8278
IS - 5
ER -