TY - JOUR
T1 - Breastfeeding and the risk of epithelial ovarian cancer in an Italian population
AU - Chiaffarino, Francesca
AU - Pelucchi, Claudio
AU - Negri, Eva
AU - Parazzini, Fabio
AU - Franceschi, Silvia
AU - Talamini, Renato
AU - Montella, Maurizio
AU - Ramazzotti, Valerio
AU - La Vecchia, Carlo
PY - 2005/8
Y1 - 2005/8
N2 - Objectives. Breastfeeding has been inversely related to the risk of ovarian cancer, but results from published studies are inconsistent. In order to provide further information, we analyzed data from a large case-control study conducted in four Italian areas. Methods. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. Results. There were inverse trends in risk with increasing duration of breastfeeding and number of children breastfed, but when parity and several other potential confounding factors were taken into account, no residual association was evident (odds ratio = 1.21 for 17 or more months of breastfeeding and 0.90 for those who had breastfed 4 or more children, as compared to women who had never breastfed). Conclusions. This study showed an inverse relation between breastfeeding and ovarian cancer risk, which however was accounted for by parity. The analyses by histologic subtypes suggested that a role of breastfeeding would be larger for serous neoplasms in the absence, however, of significant heterogeneity.
AB - Objectives. Breastfeeding has been inversely related to the risk of ovarian cancer, but results from published studies are inconsistent. In order to provide further information, we analyzed data from a large case-control study conducted in four Italian areas. Methods. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. Results. There were inverse trends in risk with increasing duration of breastfeeding and number of children breastfed, but when parity and several other potential confounding factors were taken into account, no residual association was evident (odds ratio = 1.21 for 17 or more months of breastfeeding and 0.90 for those who had breastfed 4 or more children, as compared to women who had never breastfed). Conclusions. This study showed an inverse relation between breastfeeding and ovarian cancer risk, which however was accounted for by parity. The analyses by histologic subtypes suggested that a role of breastfeeding would be larger for serous neoplasms in the absence, however, of significant heterogeneity.
KW - Breastfeeding
KW - Ovarian cancer
KW - Risk factor
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U2 - 10.1016/j.ygyno.2005.05.006
DO - 10.1016/j.ygyno.2005.05.006
M3 - Article
C2 - 15975644
AN - SCOPUS:22544455056
VL - 98
SP - 304
EP - 308
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 2
ER -