TY - JOUR
T1 - Breathing pattern and respiratory mechanics in patients with amyotrophic lateral sclerosis
AU - Vitacca, M.
AU - Clini, E.
AU - Facchetti, D.
AU - Pagani, M.
AU - Poloni, M.
AU - Porta, R.
AU - Ambrosino, N.
PY - 1997/7
Y1 - 1997/7
N2 - The aim of this study was to evaluate the time course of breathing pattern and respiratory mechanics in patients with amyotrophic literal sclerosis (ALS). A study was conducted on 25 out of 38 eligible ALS patients. Neurological status, arterial blood gases (ABGs), spirometry, breathing pattern (minute ventilation (V1E), tidal volume (VT), respiratory frequency (fR), duty cycle (duration of inspiration/duration of total breathing cycle (tI/ttot)), respiratory drive (P0.1)), respiratory mechanics (oesophageal pressure (Ppl), dynamic compliance (CL,dyn), pressure time product (PTP) and index (PTI), work of breathing (WOB)), and respiratory muscle (RM) strength as assessed by maximal oesophageal pressure (Ppl,max) were evaluated at presentation (t0) in all patients and after 6 months (t6) in 11 patients. At t0, the mcan values of the degree of neurological impairment were 60±20 and 103±30 as assessed by the Norris scale and Medical Research Council (MRC) score, respectively. From the time of the first neurological symptom, survival time ranged 7-50 months. Diurnal ABGs were normal A mild restrictive pattern was observed, a forced vital capacity (FVC) 1) % pred (r=0.53; p2O was associated with a significantly greater mortality, Ppl,max being correlated with survival (r=0.79, p1 % pred, VT and Ppl,max were significantly reduced. These results suggest a progressive deterioration in breathing pattern and in respiratory muscle strength with progression of disease.
AB - The aim of this study was to evaluate the time course of breathing pattern and respiratory mechanics in patients with amyotrophic literal sclerosis (ALS). A study was conducted on 25 out of 38 eligible ALS patients. Neurological status, arterial blood gases (ABGs), spirometry, breathing pattern (minute ventilation (V1E), tidal volume (VT), respiratory frequency (fR), duty cycle (duration of inspiration/duration of total breathing cycle (tI/ttot)), respiratory drive (P0.1)), respiratory mechanics (oesophageal pressure (Ppl), dynamic compliance (CL,dyn), pressure time product (PTP) and index (PTI), work of breathing (WOB)), and respiratory muscle (RM) strength as assessed by maximal oesophageal pressure (Ppl,max) were evaluated at presentation (t0) in all patients and after 6 months (t6) in 11 patients. At t0, the mcan values of the degree of neurological impairment were 60±20 and 103±30 as assessed by the Norris scale and Medical Research Council (MRC) score, respectively. From the time of the first neurological symptom, survival time ranged 7-50 months. Diurnal ABGs were normal A mild restrictive pattern was observed, a forced vital capacity (FVC) 1) % pred (r=0.53; p2O was associated with a significantly greater mortality, Ppl,max being correlated with survival (r=0.79, p1 % pred, VT and Ppl,max were significantly reduced. These results suggest a progressive deterioration in breathing pattern and in respiratory muscle strength with progression of disease.
KW - Motor neuron disease
KW - Neuromuscular disease
KW - Respiratory function
KW - Respiratory muscles
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U2 - 10.1183/09031936.97.10071614
DO - 10.1183/09031936.97.10071614
M3 - Article
C2 - 9230256
AN - SCOPUS:0030790147
VL - 10
SP - 1614
EP - 1621
JO - European Journal of Respiratory Diseases
JF - European Journal of Respiratory Diseases
SN - 0903-1936
IS - 7
ER -