Breathprinting and Early Diagnosis of Lung Cancer

Gaetano Rocco, Giorgio Pennazza, Marco Santonico, Filippo Longo, Raffaele Rocco, Pierfilippo Crucitti, Raffaele Antonelli Incalzi

Research output: Contribution to journalReview articlepeer-review


The electronic nose (e-nose) is a promising technology as a useful addition to the currently available modalities to achieve lung cancer diagnosis. The e-nose can assess the volatile organic compounds detected in the breath and derived from the cellular metabolism. Volatile organic compounds can be analyzed to identify the individual chemical elements as well as their pattern of expression to reproduce a sensorial combination similar to a fingerprint (breathprint). The e-nose can be used alone, mimicking the combinatorial selectivity of the human olfactory system, or as part of a multisensorial platform. This review analyzes the progress made by investigators interested in this technology as well as the perspectives for its future utilization.

Original languageEnglish
Pages (from-to)883-894
Number of pages12
JournalJournal of Thoracic Oncology
Issue number7
Publication statusPublished - Jul 1 2018


  • Biomarkers
  • Breathprint
  • Electronic nose
  • Lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine


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