Bremsstrahlung radiation detection for small animal imaging using a CCD detector

Antonello Spinelli, Federico Boschi

Research output: Contribution to journalArticle

Abstract

The use of optical methods for the detection of radionuclides is becoming an established tool for preclinical molecular imaging experiments. In this paper we present a set of proof of principle experiments showing that planar bremsstrahlung radiation images can be detected with an intensifying screen using a small animal optical imager based on charge coupled device detector.We develop a bremsstrahlung source using a 32P-ATP vial placed in a Plexiglas box, the source with an intensifying screen on top was placed inside a small animal optical imaging system. Bremsstrahlung radiation images were produced with the 32P-ATP source only and also with a pair of pliers placed between the source and the screen. We found that the pair of pliers absorption image matches the shape of the object.Spatial resolution measurements were not performed however, the bremsstrahlung image of the pliers show that the resolution is relatively poor due to a large penumbra effect.We conclude that it is possible to produce planar bremsstrahlung images using optical imaging devices.
Original languageEnglish
Pages (from-to)706 - 708
Number of pages3
JournalPhysica Medica
Volume32
Issue number5
DOIs
Publication statusPublished - May 1 2016

Fingerprint

Optical Devices
Optical Imaging
bremsstrahlung
animals
charge coupled devices
Adenosine Triphosphate
Radiation
Molecular Imaging
detectors
Polymethyl Methacrylate
radiation
Radioisotopes
adenosine triphosphate
Equipment and Supplies
penumbras
polymethyl methacrylate
radioactive isotopes
boxes
spatial resolution
optics

Keywords

  • Bremsstrahlung radiation
  • Optical imaging
  • Small animal imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)

Cite this

Bremsstrahlung radiation detection for small animal imaging using a CCD detector. / Spinelli, Antonello; Boschi, Federico.

In: Physica Medica, Vol. 32, No. 5, 01.05.2016, p. 706 - 708.

Research output: Contribution to journalArticle

Spinelli, Antonello ; Boschi, Federico. / Bremsstrahlung radiation detection for small animal imaging using a CCD detector. In: Physica Medica. 2016 ; Vol. 32, No. 5. pp. 706 - 708.
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