Brenner tumor of the ovary: A correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation

Donatella Santini, Maria Carolina Gelli, Guido Mazzoleni, Monica Ricci, Bruno Severi, Gianandrea Pasquinelli, Giuseppe Pelusi, Giuseppe Martinelli

Research output: Contribution to journalArticle

Abstract

The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuronspecific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.

Original languageEnglish
Pages (from-to)787-795
Number of pages9
JournalHuman Pathology
Volume20
Issue number8
DOIs
Publication statusPublished - 1989

Keywords

  • Brenner tumor
  • ovarian neoplasm
  • ovary

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Santini, D., Gelli, M. C., Mazzoleni, G., Ricci, M., Severi, B., Pasquinelli, G., Pelusi, G., & Martinelli, G. (1989). Brenner tumor of the ovary: A correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation. Human Pathology, 20(8), 787-795. https://doi.org/10.1016/0046-8177(89)90074-9