TY - JOUR
T1 - Brenner tumor of the ovary
T2 - A correlative histologic, histochemical, immunohistochemical, and ultrastructural investigation
AU - Santini, Donatella
AU - Gelli, Maria Carolina
AU - Mazzoleni, Guido
AU - Ricci, Monica
AU - Severi, Bruno
AU - Pasquinelli, Gianandrea
AU - Pelusi, Giuseppe
AU - Martinelli, Giuseppe
PY - 1989
Y1 - 1989
N2 - The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuronspecific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.
AB - The histologic, histochemical, immunohistochemical, and ultrastructural features of Brenner tumor (BT) were studied. BT was compared with transitional bladder cells, and close similarities between the two tissues were identified. Abundant glycogen in all cellular layers, an alcianophilic/sialomucinic surface mucous coat, and argyrophilic cells characterized both BT and bladder epithelium. Immunohistochemically, chromogranin and neuronspecific enolase reactivity was observed in all cases examined. An additional relevant finding was the presence of serotonin-storing cells in both BT and urothelium. Moreover, carcinoembryonic antigen, epithelial membrane antigen, and keratin reaction were found in BT and urothelium, indicating an additional antigenic similarity. Additionally, malignant Brenner tumor was ultrastructurally found to share many common features with the bladder tissue. The distinct histochemical, ultrastructural, and antigenic pattern of BT, primarily of the transitional type, is emphasized.
KW - Brenner tumor
KW - ovarian neoplasm
KW - ovary
UR - http://www.scopus.com/inward/record.url?scp=0024316544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024316544&partnerID=8YFLogxK
U2 - 10.1016/0046-8177(89)90074-9
DO - 10.1016/0046-8177(89)90074-9
M3 - Article
C2 - 2744751
AN - SCOPUS:0024316544
VL - 20
SP - 787
EP - 795
JO - Human Pathology
JF - Human Pathology
SN - 0046-8177
IS - 8
ER -