Bridge to Lung Transplantation by Venovenous Extracorporeal Membrane Oxygenation: A Lesson Learned on the First Four Cases

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Abstract

Extracorporeal membrane oxygenation (ECMO) is the only therapeutic option for patients with ventilation-refractory hypercapnia while awaiting lung transplantation. Moreover, there is increasing success using ECMO for definitive respiratory failure in formerly healthy patients. This report describes the use of membrane oxygenation as a bridge to lung transplantation in 2 patients on the waiting list and in 2 previously healthy patients. Our experience showed that coagulation management, critical illness myopathy, and psychological disorders were the most critical problems. One patient died at 2 days after transplantation, 1 at 3 months, and 2 returned to their pretransplantation activities. We concluded that ECMO is an adequate bridge to lung transplantation but, especially in formerly healthy patients, an awake procedure is advisable for a successful outcome.

Original languageEnglish
Pages (from-to)1259-1261
Number of pages3
JournalTransplantation Proceedings
Volume42
Issue number4
DOIs
Publication statusPublished - May 2010

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Extracorporeal Membrane Oxygenation
Lung Transplantation
Waiting Lists
Hypercapnia
Muscular Diseases
Critical Illness
Respiratory Insufficiency
Ventilation
Transplantation
Psychology
Membranes

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

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title = "Bridge to Lung Transplantation by Venovenous Extracorporeal Membrane Oxygenation: A Lesson Learned on the First Four Cases",
abstract = "Extracorporeal membrane oxygenation (ECMO) is the only therapeutic option for patients with ventilation-refractory hypercapnia while awaiting lung transplantation. Moreover, there is increasing success using ECMO for definitive respiratory failure in formerly healthy patients. This report describes the use of membrane oxygenation as a bridge to lung transplantation in 2 patients on the waiting list and in 2 previously healthy patients. Our experience showed that coagulation management, critical illness myopathy, and psychological disorders were the most critical problems. One patient died at 2 days after transplantation, 1 at 3 months, and 2 returned to their pretransplantation activities. We concluded that ECMO is an adequate bridge to lung transplantation but, especially in formerly healthy patients, an awake procedure is advisable for a successful outcome.",
author = "M. Nosotti and L. Rosso and A. Palleschi and A. Lissoni and S. Crotti and C. Marenghi and C. Colombo and D. Costantini and L. Santambrogio",
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AU - Nosotti, M.

AU - Rosso, L.

AU - Palleschi, A.

AU - Lissoni, A.

AU - Crotti, S.

AU - Marenghi, C.

AU - Colombo, C.

AU - Costantini, D.

AU - Santambrogio, L.

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