Bridging the gap between hypertrabeculation phenotype, noncompaction phenotype and left ventricular noncompaction cardiomyopathy: Journal of Cardiovascular Medicine

Vittoria Vergani, D. Lazzeroni, G. Peretto

Research output: Contribution to journalArticlepeer-review

Abstract

Left ventricular noncompaction (LVNC) is an increasingly recognised cardiomyopathy characterised by excessive trabeculation and deep intertrabecular recesses in direct communication with the left ventricular cavity. In LVNC, hypertrabeculation has been associated with heart failure, ventricular arrhythmia, and systemic thromboembolism. However, hypertrabeculation alone is not sufficient to define a subject as at risk for such complications and thus should not be sufficient to diagnose LVNC. Despite several studies having investigated parameters to predict adverse cardiovascular events, physicians have no effective tools to differentiate between clinically silent hypertrabeculation and LVNC. The aim of this paper was to review literature on LVNC diagnostic criteria and to provide an easy and accessible diagnostic algorithm to distinguish between hypertrabeculation phenotype, non-compaction phenotype and LVNC cardiomyopathy. © 2020 Lippincott Williams and Wilkins. All rights reserved.
Original languageEnglish
Pages (from-to)192-199
Number of pages8
JournalJ. Cardiovasc. Med.
Volume21
Issue number3
DOIs
Publication statusPublished - 2020

Keywords

  • athlete's heart
  • cardiomyopathy
  • hypertrabeculation
  • left ventricular noncompaction
  • gadolinium
  • cardiovascular magnetic resonance
  • CHA2DS2-VASc score
  • clinical examination
  • congestive cardiomyopathy
  • contrast enhancement
  • disease classification
  • electrocardiography
  • family history
  • gene mutation
  • genetic screening
  • genetics
  • heart failure
  • heart function
  • heart ventricle arrhythmia
  • Holter monitoring
  • human
  • hypertrophic cardiomyopathy
  • low risk patient
  • Notch signaling
  • Review
  • thromboembolism
  • ventricular noncompaction
  • algorithm
  • cardiac muscle
  • diagnostic imaging
  • differential diagnosis
  • heart left ventricle function
  • pathology
  • pathophysiology
  • phenotype
  • predictive value
  • prognosis
  • risk factor
  • Algorithms
  • Diagnosis, Differential
  • Humans
  • Isolated Noncompaction of the Ventricular Myocardium
  • Myocardium
  • Phenotype
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors
  • Ventricular Function, Left

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