Bridging the Gap Towards Awareness Detection in Disorders of Consciousness: An Experimental Study on the Mirror Neuron System

Antonino Naro, Rocco Salvatore Calabrò, Antonino Leo, Margherita Russo, Demetrio Milardi, Antonino Cannavò, Alfredo Manuli, Antonio Buda, Carmela Casella, Placido Bramanti, Alberto Cacciola, Alessia Bramanti

Research output: Contribution to journalArticle

Abstract

Advanced functional neuroimaging approaches dealing with motor imagery have disclosed covert cognitive processes in patients with disorders of consciousness (DoC). However, motor impairment and cognitive-motor dissociation can bias such approaches. Fourteen patients with post-traumatic DoC and ten healthy controls (HC) were provided with three motor tasks related to mirror neuron system (MNS) activation (movement observation, movement execution, and passive motor imagery of a movement) while recording electroencephalographic (EEG) metrics [EEG power and Granger Casualty Index (GCI)] to detect residual signs of conscious awareness. The most relevant finding was that all HCs, all patients with Minimally Conscious State and one with Unresponsive Wakefulness Syndrome demonstrated an event-related synchronization in the gamma range over left frontal regions, with high GCI values, in the passive motor imagery condition. These data significantly correlated with the level of behavioral responsiveness measured by the Coma Recovery Scale-Revised. Thus, our findings may indicate that motor tasks related to MNS can activate frontoparietal networks, although leading to different conscious processes. Hence, MNS assessment can be usefully employed to differentiate among patients with DoC.

Original languageEnglish
Pages (from-to)623-639
Number of pages17
JournalBrain Topography
Volume31
Issue number4
DOIs
Publication statusPublished - Jul 2018

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Mirror Neurons
Consciousness Disorders
Imagery (Psychotherapy)
Dissociative Disorders
Persistent Vegetative State
Functional Neuroimaging
Wakefulness
Coma
Observation

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Bridging the Gap Towards Awareness Detection in Disorders of Consciousness : An Experimental Study on the Mirror Neuron System. / Naro, Antonino; Calabrò, Rocco Salvatore; Leo, Antonino; Russo, Margherita; Milardi, Demetrio; Cannavò, Antonino; Manuli, Alfredo; Buda, Antonio; Casella, Carmela; Bramanti, Placido; Cacciola, Alberto; Bramanti, Alessia.

In: Brain Topography, Vol. 31, No. 4, 07.2018, p. 623-639.

Research output: Contribution to journalArticle

Naro, Antonino ; Calabrò, Rocco Salvatore ; Leo, Antonino ; Russo, Margherita ; Milardi, Demetrio ; Cannavò, Antonino ; Manuli, Alfredo ; Buda, Antonio ; Casella, Carmela ; Bramanti, Placido ; Cacciola, Alberto ; Bramanti, Alessia. / Bridging the Gap Towards Awareness Detection in Disorders of Consciousness : An Experimental Study on the Mirror Neuron System. In: Brain Topography. 2018 ; Vol. 31, No. 4. pp. 623-639.
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