Brief communication: Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins

Antonino Romano, Marinella Viola, Rosa Maria Guéant-Rodriguez, Francesco Gaeta, Rocco Valluzzi, Jean Louis Guéant

Research output: Contribution to journalArticle

Abstract

Background: Although clinicians avoid giving meropenem to patients with penicillin allergy because of potential cross-reactivity, the rate of cross-reactivity between penicillins and meropenem has not been prospectively determined. Objective: To assess the tolerability of meropenem in patients with documented penicillin allergy. Design: Prospective skin testing and antibiotic challenge. Setting: Allergy units of 2 Italian medical centers. Patients: 104 consecutive participants with immediate hypersensitivity reactions to penicillins and positive skin test results to at least 1 penicillin reagent. Measurements: Skin tests to meropenem and, if results were negative, challenges with escalating doses of meropenem. Results: One participant (0.9% [95% CI, 0.02% to 5.2%]) had a positive intradermal test result to meropenem. The remaining 103 participants with negative skin test results to meropenem tolerated escalating dose challenges. Limitation: Challenges were not followed by therapeutic courses. Conclusions: These data indicate a low rate of cross-reactivity between penicillins and meropenem. Therefore, the practice of avoiding meropenem therapy in penicillin-allergic patients should be reconsidered. In patients who especially require meropenem treatment, the authors recommend pretreatment skin tests because negative results indicate tolerability.

Original languageEnglish
Pages (from-to)266-269
Number of pages4
JournalAnnals of Internal Medicine
Volume146
Issue number4
Publication statusPublished - Feb 20 2007

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meropenem
Immediate Hypersensitivity
Penicillins
Communication
Skin Tests
Hypersensitivity
Intradermal Tests

ASJC Scopus subject areas

  • Medicine(all)

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Romano, A., Viola, M., Guéant-Rodriguez, R. M., Gaeta, F., Valluzzi, R., & Guéant, J. L. (2007). Brief communication: Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins. Annals of Internal Medicine, 146(4), 266-269.

Brief communication : Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins. / Romano, Antonino; Viola, Marinella; Guéant-Rodriguez, Rosa Maria; Gaeta, Francesco; Valluzzi, Rocco; Guéant, Jean Louis.

In: Annals of Internal Medicine, Vol. 146, No. 4, 20.02.2007, p. 266-269.

Research output: Contribution to journalArticle

Romano, A, Viola, M, Guéant-Rodriguez, RM, Gaeta, F, Valluzzi, R & Guéant, JL 2007, 'Brief communication: Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins', Annals of Internal Medicine, vol. 146, no. 4, pp. 266-269.
Romano A, Viola M, Guéant-Rodriguez RM, Gaeta F, Valluzzi R, Guéant JL. Brief communication: Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins. Annals of Internal Medicine. 2007 Feb 20;146(4):266-269.
Romano, Antonino ; Viola, Marinella ; Guéant-Rodriguez, Rosa Maria ; Gaeta, Francesco ; Valluzzi, Rocco ; Guéant, Jean Louis. / Brief communication : Tolerability of meropenem in patients with IgE-mediated hypersensitivity to penicillins. In: Annals of Internal Medicine. 2007 ; Vol. 146, No. 4. pp. 266-269.
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