Brief report: Serum retinol-binding protein-4, leptin, and adiponectin concentrations are related to ectopic fat accumulation

Gianluca Perseghin, Guido Lattuada, Francesco De Cobelli, Antonio Esposito, Elena Belloni, Tamara Canu, Francesca Ragogna, Paola Scifo, Alessandro Del Maschio, Livio Luzi

Research output: Contribution to journalArticlepeer-review

Abstract

Context: Serum retinol-binding protein 4 (RBP-4), leptin, and adiponectin concentrations identify insulin resistance in varied conditions, but their relationships with insulin sensitivity and ectopic fat accumulation are unclear. Objective: Our objective was to establish how these adipokines are related with intramyocellular lipid (IMCL) and intrahepatic lipid (IHL) content. Design and Setting: We assessed retrospectively serum fasting RBP-4 concentrations in 1) 53 nondiabetic individuals in which insulin sensitivity and IMCL content were assessed by means of the insulin clamp and of 1H magnetic resonance spectroscopy of the calf muscles, and 2) 140 nondiabetic individuals in which insulin sensitivity and the IHL content were assessed by means of the updated homeostasis model assessment and of 1H magnetic resonance spectroscopy. In both experiments, serum leptin and adiponectin concentrations were measured. Results: Fasting serum RBP-4, adiponectin, and leptin were associated with peripheral insulin sensitivity, were abnormal in the first-degree relatives of type 2 diabetic parents, and correlated with the soleus IMCL content and with the IHL content. The association of RBP-4 and adiponectin with insulin sensitivity was age, sex, and body mass index independent, but stepwise regression analysis suggested that RBP-4, but not adiponectin and leptin, was independently associated with insulin sensitivity. Adiponectin was independently associated with the IHL content, RBP-4, and leptin with the soleus IMCL content. Conclusion: Serum RBP-4 was a robust marker of insulin resistance. Serum RBP-4, leptin, and adiponectin concentrations reflected ectopic fat accumulation in humans.

Original languageEnglish
Pages (from-to)4883-4888
Number of pages6
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number12
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

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