Brief Report: Switch to Ritonavir-Boosted Atazanavir Plus Raltegravir in Virologically Suppressed Patients With HIV-1 Infection: A Randomized Pilot Study

Jan Van Lunzen, Anton Pozniak, Jose M. Gatell, Andrea Antinori, Isabelle Klauck, Oscar Serrano, Adyb Baakili, Olayemi Osiyemi, Heather Sevinsky, Pierre Marie Girard

Research output: Contribution to journalArticlepeer-review

Abstract

This open-label, multinational, pilot study randomized (1:2 ratio) adults with HIV-1 RNA <40 copies per milliliter and nucleos(t)ide-related safety/tolerability issues to switch to ritonavir-boosted atazanavir (ATV/r) plus tenofovir disoproxil fumarate/emtricitabine (n = 37) or the nucleos(t)ide reverse transcriptase inhibitor-sparing regimen of ATV/r plus raltegravir (RAL) (n = 72). At 24 weeks, 35/37 (94.6%) and 58/72 (80.6%) of patients, respectively, maintained virological suppression, the primary endpoint, and 1 (2.7%) and 7 (9.7%), respectively, experienced virological rebound. Corresponding 48-week proportions were 86.5%, 69.4%, 2.7%, and 12.5%, respectively. Adherence was lower and treatment discontinuation was higher with ATV/r+RAL. In conclusion, switching to ATV/r+RAL resulted in a higher virological rebound rate than switching to ATV/r plus tenofovir disoproxil fumarate/emtricitabine.

Original languageEnglish
Pages (from-to)538-43
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume71
Issue number5
DOIs
Publication statusPublished - Apr 15 2016

Keywords

  • Adult
  • Atazanavir Sulfate
  • Drug Substitution
  • Drug Therapy, Combination
  • Female
  • HIV Infections
  • HIV Integrase Inhibitors
  • HIV Protease Inhibitors
  • HIV-1
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Prospective Studies
  • Raltegravir Potassium
  • Reverse Transcriptase Inhibitors
  • Ritonavir
  • Viral Load
  • Young Adult
  • Journal Article
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

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