Broad-range neutralizing anti-influenza a human monoclonal antibodies: New perspectives in therapy and prophylaxis

Nicola Clementi, Elena Criscuolo, Matteo Castelli, Massimo Clementi

Research output: Contribution to journalArticlepeer-review

Abstract

Broadly neutralizing monoclonal antibodies (mAbs) directed against different subtypes of influenza A viruses are novel tools for the potential development of effective anti-influenza prophylactic and therapeutic strategies. In both cases, the main candidates for passive transfer and new vaccine development are represented by protective mAbs directed against influenza hemagglutinin (HA). A large number of mAbs directed against influenza HA has been developed to date. However, even if they can be useful and contribute to develop new vaccinal strategies, only few of them can be a good candidate for human administration. In this review, we will describe the most relevant human mAb directed against influenza HA able to recognize highly divergent influenza isolates and possibly useful for human therapy and prophylaxis.

Original languageEnglish
Pages (from-to)399-406
Number of pages8
JournalNew Microbiologica
Volume35
Issue number4
Publication statusPublished - 2012

Keywords

  • Antigenic drift
  • Antigenic shift
  • Bio-panning
  • Epitope characterization
  • Heterosubtypic immunity
  • Homologus immunity
  • Homosubtypic immunity
  • Monoclonal antibody
  • Neutralizing antibody
  • Phage display

ASJC Scopus subject areas

  • Microbiology (medical)

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