TY - JOUR
T1 - Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum
AU - Franciotta, Diego
AU - Bestetti, Arabella
AU - Sala, Serena
AU - Perucca, Piero
AU - Jarius, Sven
AU - Price, Richard W.
AU - Di Stefano, Anna Luisa
AU - Cinque, Paola
PY - 2009
Y1 - 2009
N2 - Members of the human herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. Real-time PCR was used to search for DNA of herpes simplex virus type-1/-2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus (EBV), human herpesvirus 6 type A/B in paired cerebrospinal fluid (CSF) and serum samples from 54 patients with MS, 34 of whom with active disease, 10 patients with other non-infectious neurological diseases, and 15 healthy individuals. All the CSF and serum samples were negative for the examined herpesviruses DNA, except one CSF sample from an MS patient, which was positive for EBV DNA. These findings do not support a role for the here-studied herpesviruses replication, whether in systemic or in the intrathecal compartment, as co-pathogenetic factors, nor as inducers of relapses, in MS.
AB - Members of the human herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. Real-time PCR was used to search for DNA of herpes simplex virus type-1/-2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus (EBV), human herpesvirus 6 type A/B in paired cerebrospinal fluid (CSF) and serum samples from 54 patients with MS, 34 of whom with active disease, 10 patients with other non-infectious neurological diseases, and 15 healthy individuals. All the CSF and serum samples were negative for the examined herpesviruses DNA, except one CSF sample from an MS patient, which was positive for EBV DNA. These findings do not support a role for the here-studied herpesviruses replication, whether in systemic or in the intrathecal compartment, as co-pathogenetic factors, nor as inducers of relapses, in MS.
KW - Cerebrospinal fluid
KW - Epstein-Barr virus
KW - Multiple sclerosis
KW - Real-time PCR
KW - Varicella-zoster virus
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M3 - Article
C2 - 20120207
AN - SCOPUS:75149150735
VL - 109
SP - 277
EP - 282
JO - Acta Neurologica Belgica
JF - Acta Neurologica Belgica
SN - 0300-9108
IS - 4
ER -