Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum

Diego Franciotta, Arabella Bestetti, Serena Sala, Piero Perucca, Sven Jarius, Richard W. Price, Anna Luisa Di Stefano, Paola Cinque

Research output: Contribution to journalArticle

Abstract

Members of the human herpesviridae family are candidates for representing the macroenvironmental factors associated with multiple sclerosis (MS) pathogenesis. Real-time PCR was used to search for DNA of herpes simplex virus type-1/-2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus (EBV), human herpesvirus 6 type A/B in paired cerebrospinal fluid (CSF) and serum samples from 54 patients with MS, 34 of whom with active disease, 10 patients with other non-infectious neurological diseases, and 15 healthy individuals. All the CSF and serum samples were negative for the examined herpesviruses DNA, except one CSF sample from an MS patient, which was positive for EBV DNA. These findings do not support a role for the here-studied herpesviruses replication, whether in systemic or in the intrathecal compartment, as co-pathogenetic factors, nor as inducers of relapses, in MS.

Original languageEnglish
Pages (from-to)277-282
Number of pages6
JournalActa Neurologica Belgica
Volume109
Issue number4
Publication statusPublished - 2009

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Keywords

  • Cerebrospinal fluid
  • Epstein-Barr virus
  • Multiple sclerosis
  • Real-time PCR
  • Varicella-zoster virus

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Franciotta, D., Bestetti, A., Sala, S., Perucca, P., Jarius, S., Price, R. W., Di Stefano, A. L., & Cinque, P. (2009). Broad screening for human herpesviridae DNA in multiple sclerosis cerebrospinal fluid and serum. Acta Neurologica Belgica, 109(4), 277-282.