Bromocriptine alone or associated with L-dopa plus benserazide in Parkinson's disease

T. A. Caraceni, I. Celano, E. Parati, F. Girotti

Research output: Contribution to journalArticle

Abstract

Twenty-six patients affected by Parkinson's disease were treated with a 2-Br-alphaergocriptine (CB 154): 14 cases were given CB 154 alone, and 12 were given CB 154 along with L-dopa plus benserazide (Madopar). Both CB 154 and combined therapy (CB 154+Madopar) induced a significant improvement in total disability score, tremor, rigidity, akinesia, selfsufficiency, and some motor performance tests (dynamic tests). No significant difference was found between results obtained with CB 154 therapy and with Madopar treatment, while the improvement induced by combined therapy (CB 154 +Madopar) was significantly higher than that obtained by Madopar alone. The adverse reactions caused by CB 154 alone or associated with Madopar are similar to those observed during other dopaminergic treatment. CB 154 alone or combined with Madopar appears to be a useful advance in the management of Parkinson's disease.

Original languageEnglish
Pages (from-to)1142-1146
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume40
Issue number12
DOIs
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

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