Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke

M. Bragoni, M. Altieri, V. Di Piero, A. Padovani, C. Mostardini, G. L. Lenzi

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8; p <.004), reading-comprehension (F, 8.1; p <.003), repetition (F, 3.8; p <.01) and verbal latency (F, 4.9; p <.01). High dosage of BR promoted a late recovery in stable chronic non-fluent aphasia and this improvement was enhanced by combination with ST.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalNeurological Sciences
Volume21
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Speech Therapy
Bromocriptine
Aphasia
Stroke
Language Tests
Clinical Protocols
Double-Blind Method
Reading
Language
Placebos

Keywords

  • Aphasia
  • Bromocriptine
  • Recovery
  • Speech therapy
  • Stroke

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Bragoni, M., Altieri, M., Di Piero, V., Padovani, A., Mostardini, C., & Lenzi, G. L. (2000). Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke. Neurological Sciences, 21(1), 19-22. https://doi.org/10.1007/s100720070114

Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke. / Bragoni, M.; Altieri, M.; Di Piero, V.; Padovani, A.; Mostardini, C.; Lenzi, G. L.

In: Neurological Sciences, Vol. 21, No. 1, 2000, p. 19-22.

Research output: Contribution to journalArticle

Bragoni, M, Altieri, M, Di Piero, V, Padovani, A, Mostardini, C & Lenzi, GL 2000, 'Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke', Neurological Sciences, vol. 21, no. 1, pp. 19-22. https://doi.org/10.1007/s100720070114
Bragoni M, Altieri M, Di Piero V, Padovani A, Mostardini C, Lenzi GL. Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke. Neurological Sciences. 2000;21(1):19-22. https://doi.org/10.1007/s100720070114
Bragoni, M. ; Altieri, M. ; Di Piero, V. ; Padovani, A. ; Mostardini, C. ; Lenzi, G. L. / Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke. In: Neurological Sciences. 2000 ; Vol. 21, No. 1. pp. 19-22.
@article{615dba891c5b429b915dc6f4dd5f4266,
title = "Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke",
abstract = "The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8; p <.004), reading-comprehension (F, 8.1; p <.003), repetition (F, 3.8; p <.01) and verbal latency (F, 4.9; p <.01). High dosage of BR promoted a late recovery in stable chronic non-fluent aphasia and this improvement was enhanced by combination with ST.",
keywords = "Aphasia, Bromocriptine, Recovery, Speech therapy, Stroke",
author = "M. Bragoni and M. Altieri and {Di Piero}, V. and A. Padovani and C. Mostardini and Lenzi, {G. L.}",
year = "2000",
doi = "10.1007/s100720070114",
language = "English",
volume = "21",
pages = "19--22",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "1",

}

TY - JOUR

T1 - Bromocriptine and speech therapy in non-fluent chronic aphasia after stroke

AU - Bragoni, M.

AU - Altieri, M.

AU - Di Piero, V.

AU - Padovani, A.

AU - Mostardini, C.

AU - Lenzi, G. L.

PY - 2000

Y1 - 2000

N2 - The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8; p <.004), reading-comprehension (F, 8.1; p <.003), repetition (F, 3.8; p <.01) and verbal latency (F, 4.9; p <.01). High dosage of BR promoted a late recovery in stable chronic non-fluent aphasia and this improvement was enhanced by combination with ST.

AB - The objectives of this study were to investigate the efficacy of bromocriptine (BR) combined with speech therapy (ST) to improve a late recovery in non-fluent aphasic stroke patients. We performed a double-blind study with high dosage of BR, prescribed according to a dose-escalating protocol, comprehensive of clinical data, relatives' impression, and language evaluations. The study was divided into the following phases: t-0, inclusion; t-30, language re-test to evaluate the stability of aphasia; t-90, placebo (PL) and ST; t-150, BR and ST; t-210, BR; t-270, wash-out. With respect to the baseline assessment, a significant improvement was observed in the following tests: dictation (F, 4.8; p <.004), reading-comprehension (F, 8.1; p <.003), repetition (F, 3.8; p <.01) and verbal latency (F, 4.9; p <.01). High dosage of BR promoted a late recovery in stable chronic non-fluent aphasia and this improvement was enhanced by combination with ST.

KW - Aphasia

KW - Bromocriptine

KW - Recovery

KW - Speech therapy

KW - Stroke

UR - http://www.scopus.com/inward/record.url?scp=0033946907&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033946907&partnerID=8YFLogxK

U2 - 10.1007/s100720070114

DO - 10.1007/s100720070114

M3 - Article

VL - 21

SP - 19

EP - 22

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 1

ER -