Bromocriptine test in the evaluation of patients with syncope of unknown aetiology: A case-control study

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Abstract

The aim of the present study was to evaluate, through a case-control study, the specificity of the upright tilt test with bromocriptine as a marker of neurally mediated syncope of unknown aetiology. We have compared upright tilt test with bromocriptine (2.5 mg p.o.) in patients with syncope of unknown aetiology and controls. A total of 23 patients and controls matched by age and sex had upright tilt test with bromocriptine. The upright tilt test procedure consisted of 10 min in supine position, 10 min of 60°head-up tilt and a further 10 min with the subject supine; this procedure was performed in baseline condition and 60, 120, 180 and 240 min after the administration of bromocriptine. The protocol end points were the development of syncope or presyncope in association with hypotension with or without bradycardia. A positive response to bromocriptine test was found in 78% (95% CI, 61% to 95%) of patients and in 13% (95% CI, 0% to 26%) of controls (P

Original languageEnglish
Pages (from-to)297-302
Number of pages6
JournalActa Neurologica Scandinavica
Volume99
Issue number5
Publication statusPublished - 1999

Keywords

  • Bromocriptine
  • Dopaminergic supersensitivity
  • Neuromediated syncope
  • Upright tilt test

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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