Bronchiolar columnar cell dysplasia - Genetic analysis of a novel preneoplastic lesion of peripheral lung

Reinhard Ullmann, Massimo Bongiovanni, Iris Halbwedl, Susanna Petzmann, Margit Gogg-Kammerer, Anna Sapino, Mauro Papotti, Gianni Bussolati, Helmut H. Popper

Research output: Contribution to journalArticle

Abstract

Atypical adenomatous hyperplasia is the only known precursor lesion of lung adenocarcinomas (ACs) so far. Here, we describe a new dysplastic lesion in the bronchioles of peripheral lung for which we propose the name bronchiolar columnar cell dysplasia (BCCD). Eight of fourteen BCCDs were successfully analyzed by means of comparative genomic hybridization (CGH). The average number of chromosomal aberrations was 2.6 in BCCD and 14.7 in concomitant AC. Among the aberrations were losses of 3p, 9, 13, 14 and gains of 1q, 17, 19q and 20q. Summarizing our data from morphological and genetic analysis, we conclude that BCCD is a preneoplasia of the bronchiolar epithelium and most probably represents an additional precursor lesion of lung adenocarcinomas.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalVirchows Archiv
Volume442
Issue number5
Publication statusPublished - May 1 2003

Keywords

  • Bronchiolar dysplasia
  • Comparative genomic hybridization
  • Lung adenocarcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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    Ullmann, R., Bongiovanni, M., Halbwedl, I., Petzmann, S., Gogg-Kammerer, M., Sapino, A., Papotti, M., Bussolati, G., & Popper, H. H. (2003). Bronchiolar columnar cell dysplasia - Genetic analysis of a novel preneoplastic lesion of peripheral lung. Virchows Archiv, 442(5), 429-436.