Bronchodilation test in patients with allergic rhinitis

G. Ciprandi, A. Signori, M. A. Tosca, I. Cirillo

Research output: Contribution to journalArticlepeer-review


Background: Allergic rhinitis (AR) may be considered a risk factor for the onset of asthma. Recently, it has been reported that forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) may predict a positive response to bronchodilation test in asthmatic children. The aim of this study was to evaluate a large group of adult AR patients to investigate the frequency of response to bronchodilation test and FEF25-75 values. Methods: One thousand four hundred and sixty-nine consecutive patients suffering from persistent AR were evaluated. Clinical examination, spirometry, and bronchodilation test were performed in all patients. Results: In this study, 62.9% of patients had reversibility to bronchodilation test and 17.8% had impaired FEF25-75 values (≤65% of predicted). Impaired FEF 25-75 values associated with longer rhinitis duration may predict reversibility to bronchodilation test (OR = 11.3; P <0.001). In addition, a FEF25-75 cutoff value ≤71% of predicted may already discriminate patients with reversibility. Conclusions: This study highlights that about two-thirds of patients with persistent AR may be considered at risk of becoming asthmatic. This finding should be adequately considered as a precocious spirometry may allow the early detection of patients prone to develop asthma and consequently to treat them.

Original languageEnglish
Pages (from-to)694-698
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number5
Publication statusPublished - May 2011


  • allergic rhinitis
  • asthma
  • bronchodilation test
  • FEF
  • reversibility
  • rhinitis duration

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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