Bronchoscopic diagnosis of Langerhans cell histiocytosis and lymphangioleiomyomatosis

Sergio Harari, Olga Torre, Roberto Cassandro, Angelo M. Taveira-Dasilva, Joel Moss

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Limited data are available regarding the role of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBB) as diagnostic tools in pulmonary Langerhans' Cell Histiocytosis (LCH) and lymphangioleiomyomatosis (LAM). The aim of this study was to review our experience regarding the value of these two techniques in the diagnosis of these cystic lung diseases. Records of 452 patients with the presumptive diagnosis of interstitial lung disease were reviewed; 67 had a clinical-radiological diagnosis of either LCH (n = 27) or LAM (n = 40). Of 16 patients with LCH who underwent BAL, four specimens (25%) contained cells which had positive immunoreactivity for CD1a. Of three patients with negative BAL fluid who had TBB, only one had a positive tissue diagnosis. Ten LCH patients were diagnosed by surgical lung biopsy of which five had negative BAL fluid. The remaining 12 patients were diagnosed by clinical and radiologic features. Standard examination of BAL fluid was of no diagnostic value in LAM. TBB was performed in seven patients and was diagnostic in six, not resulting in complications. All 13 patients who underwent surgical lung biopsies had a positive histopathologic diagnosis The remaining 21 patients were diagnosed by clinical and radiologic features. We suggest that BAL may assist in the diagnosis of LCH whereas TBB may be useful in the diagnosis of LAM, thus avoiding the need for surgical biopsy.

Original languageEnglish
Pages (from-to)1286-1292
Number of pages7
JournalRespiratory Medicine
Volume106
Issue number9
DOIs
Publication statusPublished - Sep 2012

Fingerprint

Lymphangioleiomyomatosis
Langerhans Cell Histiocytosis
Biopsy
Lung
Bronchoalveolar Lavage Fluid
Bronchoalveolar Lavage
Interstitial Lung Diseases

Keywords

  • Fiberoptic bronchoscopy
  • Interstitial lung diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Bronchoscopic diagnosis of Langerhans cell histiocytosis and lymphangioleiomyomatosis. / Harari, Sergio; Torre, Olga; Cassandro, Roberto; Taveira-Dasilva, Angelo M.; Moss, Joel.

In: Respiratory Medicine, Vol. 106, No. 9, 09.2012, p. 1286-1292.

Research output: Contribution to journalArticle

@article{50200584b25447ec86680d8d872b6927,
title = "Bronchoscopic diagnosis of Langerhans cell histiocytosis and lymphangioleiomyomatosis",
abstract = "Limited data are available regarding the role of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBB) as diagnostic tools in pulmonary Langerhans' Cell Histiocytosis (LCH) and lymphangioleiomyomatosis (LAM). The aim of this study was to review our experience regarding the value of these two techniques in the diagnosis of these cystic lung diseases. Records of 452 patients with the presumptive diagnosis of interstitial lung disease were reviewed; 67 had a clinical-radiological diagnosis of either LCH (n = 27) or LAM (n = 40). Of 16 patients with LCH who underwent BAL, four specimens (25{\%}) contained cells which had positive immunoreactivity for CD1a. Of three patients with negative BAL fluid who had TBB, only one had a positive tissue diagnosis. Ten LCH patients were diagnosed by surgical lung biopsy of which five had negative BAL fluid. The remaining 12 patients were diagnosed by clinical and radiologic features. Standard examination of BAL fluid was of no diagnostic value in LAM. TBB was performed in seven patients and was diagnostic in six, not resulting in complications. All 13 patients who underwent surgical lung biopsies had a positive histopathologic diagnosis The remaining 21 patients were diagnosed by clinical and radiologic features. We suggest that BAL may assist in the diagnosis of LCH whereas TBB may be useful in the diagnosis of LAM, thus avoiding the need for surgical biopsy.",
keywords = "Fiberoptic bronchoscopy, Interstitial lung diseases",
author = "Sergio Harari and Olga Torre and Roberto Cassandro and Taveira-Dasilva, {Angelo M.} and Joel Moss",
year = "2012",
month = "9",
doi = "10.1016/j.rmed.2012.06.012",
language = "English",
volume = "106",
pages = "1286--1292",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",
number = "9",

}

TY - JOUR

T1 - Bronchoscopic diagnosis of Langerhans cell histiocytosis and lymphangioleiomyomatosis

AU - Harari, Sergio

AU - Torre, Olga

AU - Cassandro, Roberto

AU - Taveira-Dasilva, Angelo M.

AU - Moss, Joel

PY - 2012/9

Y1 - 2012/9

N2 - Limited data are available regarding the role of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBB) as diagnostic tools in pulmonary Langerhans' Cell Histiocytosis (LCH) and lymphangioleiomyomatosis (LAM). The aim of this study was to review our experience regarding the value of these two techniques in the diagnosis of these cystic lung diseases. Records of 452 patients with the presumptive diagnosis of interstitial lung disease were reviewed; 67 had a clinical-radiological diagnosis of either LCH (n = 27) or LAM (n = 40). Of 16 patients with LCH who underwent BAL, four specimens (25%) contained cells which had positive immunoreactivity for CD1a. Of three patients with negative BAL fluid who had TBB, only one had a positive tissue diagnosis. Ten LCH patients were diagnosed by surgical lung biopsy of which five had negative BAL fluid. The remaining 12 patients were diagnosed by clinical and radiologic features. Standard examination of BAL fluid was of no diagnostic value in LAM. TBB was performed in seven patients and was diagnostic in six, not resulting in complications. All 13 patients who underwent surgical lung biopsies had a positive histopathologic diagnosis The remaining 21 patients were diagnosed by clinical and radiologic features. We suggest that BAL may assist in the diagnosis of LCH whereas TBB may be useful in the diagnosis of LAM, thus avoiding the need for surgical biopsy.

AB - Limited data are available regarding the role of bronchoalveolar lavage (BAL) and transbronchial lung biopsy (TBB) as diagnostic tools in pulmonary Langerhans' Cell Histiocytosis (LCH) and lymphangioleiomyomatosis (LAM). The aim of this study was to review our experience regarding the value of these two techniques in the diagnosis of these cystic lung diseases. Records of 452 patients with the presumptive diagnosis of interstitial lung disease were reviewed; 67 had a clinical-radiological diagnosis of either LCH (n = 27) or LAM (n = 40). Of 16 patients with LCH who underwent BAL, four specimens (25%) contained cells which had positive immunoreactivity for CD1a. Of three patients with negative BAL fluid who had TBB, only one had a positive tissue diagnosis. Ten LCH patients were diagnosed by surgical lung biopsy of which five had negative BAL fluid. The remaining 12 patients were diagnosed by clinical and radiologic features. Standard examination of BAL fluid was of no diagnostic value in LAM. TBB was performed in seven patients and was diagnostic in six, not resulting in complications. All 13 patients who underwent surgical lung biopsies had a positive histopathologic diagnosis The remaining 21 patients were diagnosed by clinical and radiologic features. We suggest that BAL may assist in the diagnosis of LCH whereas TBB may be useful in the diagnosis of LAM, thus avoiding the need for surgical biopsy.

KW - Fiberoptic bronchoscopy

KW - Interstitial lung diseases

UR - http://www.scopus.com/inward/record.url?scp=84864584731&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84864584731&partnerID=8YFLogxK

U2 - 10.1016/j.rmed.2012.06.012

DO - 10.1016/j.rmed.2012.06.012

M3 - Article

C2 - 22770823

AN - SCOPUS:84864584731

VL - 106

SP - 1286

EP - 1292

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 9

ER -