CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE

Translated title of the contribution: Bronchospasm management by means of ipratropium, beclomethasone and their combination

C. F. Donner, C. Fracchia, F. Ioli

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

The authors assessed bronchospasm management in a group of 10 patients aged 44 to 72 yr with chronic reversible bronchoconstriction (4 patients with chronic bronchial asthma and 6 with chronic obstructive bronchitis). A single-blind, cross-over, clinical trial was undertaken according to a random scheme by using, successively, three different treatments (ipratropium alone, beclomethasone alone, the two drugs associated to be noted that in the association the daily doses of both components were reduced to 5/8 of the doses of the non-associated drugs): each treatment lasted 8 days with 3 days of wash-out. The modifications induced by the drugs were evaluated by the assessment of the pulmonary function (FEV1, FRC, FEV1/VCx100,SGaw, FEF(25-75),pH, PaO2, PaCO2), and the daily check of FEV1, of the main cardiovascular parameters (HR, BP max, BP min) and of the possible subjective or objective side-effects. Before the beginning of the trial all patients were treated continuously with theophylline, beta-2-sympathomimetics and corticosteroids, differently associated. The functional variables showed no significant changes between the data at the end of the previous treatment and the same data at the end of every aerosol-administered treatment. Neither subjective nor objective side-effects were observed during any treatment. These results confirm our opinion that beclomethasone dipropionate and ipratropium bromide administered by aerosol are a safe and effective alternative to oral and parenteral drugs in many cases of chronic reversible bronchoconstriction.

Original languageItalian
Title of host publicationGiornale Italiano della Malattie del Torace
Pages307-310
Number of pages4
Volume34
Edition4
Publication statusPublished - 1980

Fingerprint

Ipratropium
Beclomethasone
Bronchial Spasm
Bronchoconstriction
Aerosols
Pharmaceutical Preparations
Therapeutics
Sympathomimetics
Chronic Bronchitis
Theophylline
Cross-Over Studies
Adrenal Cortex Hormones
Asthma
Clinical Trials
Lung

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Donner, C. F., Fracchia, C., & Ioli, F. (1980). CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE. In Giornale Italiano della Malattie del Torace (4 ed., Vol. 34, pp. 307-310)

CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE. / Donner, C. F.; Fracchia, C.; Ioli, F.

Giornale Italiano della Malattie del Torace. Vol. 34 4. ed. 1980. p. 307-310.

Research output: Chapter in Book/Report/Conference proceedingChapter

Donner, CF, Fracchia, C & Ioli, F 1980, CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE. in Giornale Italiano della Malattie del Torace. 4 edn, vol. 34, pp. 307-310.
Donner CF, Fracchia C, Ioli F. CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE. In Giornale Italiano della Malattie del Torace. 4 ed. Vol. 34. 1980. p. 307-310
Donner, C. F. ; Fracchia, C. ; Ioli, F. / CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE. Giornale Italiano della Malattie del Torace. Vol. 34 4. ed. 1980. pp. 307-310
@inbook{c9b209f3836d4bd9876f4b8156f17943,
title = "CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE",
abstract = "The authors assessed bronchospasm management in a group of 10 patients aged 44 to 72 yr with chronic reversible bronchoconstriction (4 patients with chronic bronchial asthma and 6 with chronic obstructive bronchitis). A single-blind, cross-over, clinical trial was undertaken according to a random scheme by using, successively, three different treatments (ipratropium alone, beclomethasone alone, the two drugs associated to be noted that in the association the daily doses of both components were reduced to 5/8 of the doses of the non-associated drugs): each treatment lasted 8 days with 3 days of wash-out. The modifications induced by the drugs were evaluated by the assessment of the pulmonary function (FEV1, FRC, FEV1/VCx100,SGaw, FEF(25-75),pH, PaO2, PaCO2), and the daily check of FEV1, of the main cardiovascular parameters (HR, BP max, BP min) and of the possible subjective or objective side-effects. Before the beginning of the trial all patients were treated continuously with theophylline, beta-2-sympathomimetics and corticosteroids, differently associated. The functional variables showed no significant changes between the data at the end of the previous treatment and the same data at the end of every aerosol-administered treatment. Neither subjective nor objective side-effects were observed during any treatment. These results confirm our opinion that beclomethasone dipropionate and ipratropium bromide administered by aerosol are a safe and effective alternative to oral and parenteral drugs in many cases of chronic reversible bronchoconstriction.",
author = "Donner, {C. F.} and C. Fracchia and F. Ioli",
year = "1980",
language = "Italian",
volume = "34",
pages = "307--310",
booktitle = "Giornale Italiano della Malattie del Torace",
edition = "4",

}

TY - CHAP

T1 - CONTROLLO DEL BRONCOSPASMO MEDIANTE IPRATROPIO, BECLOMETASONE E LORO ASSOCIAZIONE

AU - Donner, C. F.

AU - Fracchia, C.

AU - Ioli, F.

PY - 1980

Y1 - 1980

N2 - The authors assessed bronchospasm management in a group of 10 patients aged 44 to 72 yr with chronic reversible bronchoconstriction (4 patients with chronic bronchial asthma and 6 with chronic obstructive bronchitis). A single-blind, cross-over, clinical trial was undertaken according to a random scheme by using, successively, three different treatments (ipratropium alone, beclomethasone alone, the two drugs associated to be noted that in the association the daily doses of both components were reduced to 5/8 of the doses of the non-associated drugs): each treatment lasted 8 days with 3 days of wash-out. The modifications induced by the drugs were evaluated by the assessment of the pulmonary function (FEV1, FRC, FEV1/VCx100,SGaw, FEF(25-75),pH, PaO2, PaCO2), and the daily check of FEV1, of the main cardiovascular parameters (HR, BP max, BP min) and of the possible subjective or objective side-effects. Before the beginning of the trial all patients were treated continuously with theophylline, beta-2-sympathomimetics and corticosteroids, differently associated. The functional variables showed no significant changes between the data at the end of the previous treatment and the same data at the end of every aerosol-administered treatment. Neither subjective nor objective side-effects were observed during any treatment. These results confirm our opinion that beclomethasone dipropionate and ipratropium bromide administered by aerosol are a safe and effective alternative to oral and parenteral drugs in many cases of chronic reversible bronchoconstriction.

AB - The authors assessed bronchospasm management in a group of 10 patients aged 44 to 72 yr with chronic reversible bronchoconstriction (4 patients with chronic bronchial asthma and 6 with chronic obstructive bronchitis). A single-blind, cross-over, clinical trial was undertaken according to a random scheme by using, successively, three different treatments (ipratropium alone, beclomethasone alone, the two drugs associated to be noted that in the association the daily doses of both components were reduced to 5/8 of the doses of the non-associated drugs): each treatment lasted 8 days with 3 days of wash-out. The modifications induced by the drugs were evaluated by the assessment of the pulmonary function (FEV1, FRC, FEV1/VCx100,SGaw, FEF(25-75),pH, PaO2, PaCO2), and the daily check of FEV1, of the main cardiovascular parameters (HR, BP max, BP min) and of the possible subjective or objective side-effects. Before the beginning of the trial all patients were treated continuously with theophylline, beta-2-sympathomimetics and corticosteroids, differently associated. The functional variables showed no significant changes between the data at the end of the previous treatment and the same data at the end of every aerosol-administered treatment. Neither subjective nor objective side-effects were observed during any treatment. These results confirm our opinion that beclomethasone dipropionate and ipratropium bromide administered by aerosol are a safe and effective alternative to oral and parenteral drugs in many cases of chronic reversible bronchoconstriction.

UR - http://www.scopus.com/inward/record.url?scp=0019252393&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019252393&partnerID=8YFLogxK

M3 - Capitolo

AN - SCOPUS:0019252393

VL - 34

SP - 307

EP - 310

BT - Giornale Italiano della Malattie del Torace

ER -