BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients

Jacopo Tagliabue, Marco Farina, Enrico Imbasciati, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

Since bone mineral density may be influenced by the polymorphisms of the vitamin D receptor (VDR) gene, we studied whether VDR genotypes might drive the progression toward hyperparathyroidism or hypoparathyroidism in patients with end-stage renal disease. On the basis of their parathyroid hormone (PTH) levels, we divided 99 patients undergoing dialysis into 2 groups: 56 patients with hypoparathyroidism (PTH <104 pg/mL [<11 pmol/L]) and 43 with hyperparathyroidism (PTH > 261 pg/mL [> 27.5 pmol/L]). The BB polymorphism was more frequent in patients with hypoparathyroidism (34%) than in patients with hyperparathyroidism (16%), but the difference did not reach statistical significance. Patients with the B allele and BB genotype had a significantly lower dialytic age and serum PTH and alkaline phosphatase levels than patients with the b allele and bb genotype. These results suggest that in end-stage renal disease, the BB genotype may mark a higher risk of developing hypoparathyroidism and diminished bone turnover.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume112
Issue number3
Publication statusPublished - 1999

Keywords

  • End-stage renal disease
  • Hyperparathyroidism
  • Hypoparathyroidism
  • Vitamin D receptor gene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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