BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients

Jacopo Tagliabue, Marco Farina, Enrico Imbasciati, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journalArticle

Abstract

Since bone mineral density may be influenced by the polymorphisms of the vitamin D receptor (VDR) gene, we studied whether VDR genotypes might drive the progression toward hyperparathyroidism or hypoparathyroidism in patients with end-stage renal disease. On the basis of their parathyroid hormone (PTH) levels, we divided 99 patients undergoing dialysis into 2 groups: 56 patients with hypoparathyroidism (PTH <104 pg/mL [<11 pmol/L]) and 43 with hyperparathyroidism (PTH > 261 pg/mL [> 27.5 pmol/L]). The BB polymorphism was more frequent in patients with hypoparathyroidism (34%) than in patients with hyperparathyroidism (16%), but the difference did not reach statistical significance. Patients with the B allele and BB genotype had a significantly lower dialytic age and serum PTH and alkaline phosphatase levels than patients with the b allele and bb genotype. These results suggest that in end-stage renal disease, the BB genotype may mark a higher risk of developing hypoparathyroidism and diminished bone turnover.

Original languageEnglish
Pages (from-to)366-370
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume112
Issue number3
Publication statusPublished - 1999

Fingerprint

Calcitriol Receptors
Dialysis
Hypoparathyroidism
Genes
Parathyroid Hormone
Genotype
Hyperparathyroidism
Chronic Kidney Failure
Alleles
Bone Remodeling
Bone Density
Alkaline Phosphatase
Serum

Keywords

  • End-stage renal disease
  • Hyperparathyroidism
  • Hypoparathyroidism
  • Vitamin D receptor gene

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Tagliabue, J., Farina, M., Imbasciati, E., Vergani, C., & Annoni, G. (1999). BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients. American Journal of Clinical Pathology, 112(3), 366-370.

BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients. / Tagliabue, Jacopo; Farina, Marco; Imbasciati, Enrico; Vergani, Carlo; Annoni, Giorgio.

In: American Journal of Clinical Pathology, Vol. 112, No. 3, 1999, p. 366-370.

Research output: Contribution to journalArticle

Tagliabue, J, Farina, M, Imbasciati, E, Vergani, C & Annoni, G 1999, 'BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients', American Journal of Clinical Pathology, vol. 112, no. 3, pp. 366-370.
Tagliabue, Jacopo ; Farina, Marco ; Imbasciati, Enrico ; Vergani, Carlo ; Annoni, Giorgio. / BsmI polymorphism of the vitamin D receptor gene in hyperparathyroid or hypoparathyroid dialysis patients. In: American Journal of Clinical Pathology. 1999 ; Vol. 112, No. 3. pp. 366-370.
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