Bsx, an evolutionary conserved Brain Specific homeoboX gene expressed in the septum, epiphysis, mammillary bodies and arcuate nucleus

Mattia Cremona, Elena Colombo, Massimiliano Andreazzoli, Giulio Cossu, Vania Broccoli

Research output: Contribution to journalArticle

Abstract

Shaping and orchestrating the genetic program involved in embryonic modelling of brain structures is a major function played by homeobox containing genes. Recently, analysis of conditional mouse mutants has pointed out additional roles in supporting adult brain functional activities. During a search for novel homeobox genes in the public released genomic sequences derived by the Human and Mouse genome projects, we were able to identify the mouse homologue of the Drosophila brain specific homeobox gene. We named it Bsx and characterized its expression in embryonic and post-natal mouse brain. Interestingly, Bsx shows an expression pattern restricted to a few specific developing brain structures. Pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus are the only brain structures where we detected Bsx transcriptional activity, which is maintained also after birth. In particular, Bsx might be considered an important molecular marker for early embryonic stages of epiphysis development, being specifically expressed in this neural structure from E9.5 onwards.

Original languageEnglish
Pages (from-to)47-51
Number of pages5
JournalGene Expression Patterns
Volume4
Issue number1
DOIs
Publication statusPublished - Jan 2004

Keywords

  • Arcuate nucleus
  • Brain expressed homeobox
  • Bsx
  • Diencephalon
  • Epiphysis
  • Ghrelin
  • Growth hormone releasing hormone
  • Gsh1
  • Homeodomain
  • Hypothalamus
  • Leptin
  • Mammillary body
  • Orthopedia
  • Pineal gland
  • Septum
  • Somatostatin
  • Telencephalon

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Developmental Neuroscience

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