"Bubble-like" lung metastases in osteosarcoma patients

Antonio Briccoli, Michele Rocca, Maria Cristina Salone, Maria Di Fiore, Daniel Vanel, Alba Balladelli, Marco Alberghini

Research output: Contribution to journalArticlepeer-review


Purpose: Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases. Results: Two patients with osteogenic sarcoma developed radiological evidence of pulmonary "bubble-like" cavitation several years following completion of chemotherapy. In one patient the "bubble-like" cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases. Conclusion: The two cases suggest that onset of "bubble-like" cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalEuropean Journal of Radiology
Issue number1
Publication statusPublished - Jul 2009


  • Cavitary metastasis/lung
  • Computed tomography
  • Osteosarcoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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