"Bubble-like" lung metastases in osteosarcoma patients

Antonio Briccoli; Michele Rocca; Maria Cristina Salone; Maria Di Fiore; Daniel Vanel; Alba Balladelli; Marco Alberghini

doi:10.1016/j.ejrad.2008.03.001

"Bubble-like" lung metastases in osteosarcoma patients

Antonio Briccoli, Michele Rocca, Maria Cristina Salone, Maria Di Fiore, Daniel Vanel, Alba Balladelli, Marco Alberghini

Istituti Ortopedici Rizzoli

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases. Results: Two patients with osteogenic sarcoma developed radiological evidence of pulmonary "bubble-like" cavitation several years following completion of chemotherapy. In one patient the "bubble-like" cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases. Conclusion: The two cases suggest that onset of "bubble-like" cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.

Original language	English
Pages (from-to)	144-146
Number of pages	3
Journal	European Journal of Radiology
Volume	71
Issue number	1
DOIs	https://doi.org/10.1016/j.ejrad.2008.03.001
Publication status	Published - Jul 2009

Keywords

Cavitary metastasis/lung
Computed tomography
Osteosarcoma

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.ejrad.2008.03.001

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Cite this

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title = "{"}Bubble-like{"} lung metastases in osteosarcoma patients",

abstract = "Purpose: Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases. Results: Two patients with osteogenic sarcoma developed radiological evidence of pulmonary {"}bubble-like{"} cavitation several years following completion of chemotherapy. In one patient the {"}bubble-like{"} cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases. Conclusion: The two cases suggest that onset of {"}bubble-like{"} cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.",

keywords = "Cavitary metastasis/lung, Computed tomography, Osteosarcoma",

author = "Antonio Briccoli and Michele Rocca and Salone, {Maria Cristina} and {Di Fiore}, Maria and Daniel Vanel and Alba Balladelli and Marco Alberghini",

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T1 - "Bubble-like" lung metastases in osteosarcoma patients

AU - Briccoli, Antonio

AU - Rocca, Michele

AU - Salone, Maria Cristina

AU - Di Fiore, Maria

AU - Vanel, Daniel

AU - Balladelli, Alba

AU - Alberghini, Marco

PY - 2009/7

Y1 - 2009/7

N2 - Purpose: Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases. Results: Two patients with osteogenic sarcoma developed radiological evidence of pulmonary "bubble-like" cavitation several years following completion of chemotherapy. In one patient the "bubble-like" cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases. Conclusion: The two cases suggest that onset of "bubble-like" cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.

AB - Purpose: Cavitation of pulmonary metastases have been reported by several authors either as a spontaneous phenomenon or as a consequence of chemotherapy. We present two cases, with this type of image in follow-up, and 20-45 months after the end of treatment. This was the first sign of pulmonary metastases. Results: Two patients with osteogenic sarcoma developed radiological evidence of pulmonary "bubble-like" cavitation several years following completion of chemotherapy. In one patient the "bubble-like" cavitation transformed into a solid nodule. Both patients had surgical resections of all pulmonary lesions, and histology confirmed presence of viable osteosarcoma metastases. Conclusion: The two cases suggest that onset of "bubble-like" cavitation in lung parenchyma of osteosarcoma patients may be the first sign of pulmonary metastases.

KW - Cavitary metastasis/lung

KW - Computed tomography

KW - Osteosarcoma

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