Building up the inactive X chromosome

Maria R. Matarazzo, Andrea Cerase, Maurizio D'Esposito

Research output: Contribution to journalArticlepeer-review

Abstract

The compensation of the different level of transcripts of X-linked genes in male and female mammals is achieved through X chromosome inactivation, a complex process that differentially regulates the sex chromosomes of female cells. This mechanism has been dissected at evolutionary, genetic and molecular levels: here, we discuss some of the latest examples that illustrate better these intricate connections, focusing particularly on the emerging role of spatial and three-dimensional chromatin arrangements in the building of this special chromosome, the inactive X chromosome.

Original languageEnglish
Pages (from-to)63-70
Number of pages8
JournalBiology of the cell / under the auspices of the European Cell Biology Organization
Volume100
Issue number1
DOIs
Publication statusPublished - Jan 2008

Keywords

  • Epigenetic mechanism
  • Nuclear architecture
  • Pseudoautosomal region 2 (PAR2)
  • X chromosome inactivation
  • X-inactive-specific transcript

ASJC Scopus subject areas

  • Cell Biology

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