Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study

Marco Peluso, Luisa Airoldi, Armelle Munnia, Alessandro Colombi, Fabrizio Veglia, Herman Autrup, Alison Dunning, Seymour Garte, Emmanuelle Gormally, Christian Malaveille, Giuseppe Matullo, Kim Overvad, Ole Raaschou-Nielsen, Francoise Clavel-Chapelon, Jacob Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Rosario TuminoSalvatore Panico, Bas H. Bueno-De-Mesquita, Petra H. Peeters, Merethe Kumle, Antonio Agudo, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, María Jose Tormo, José Ramón Quiros, Goran Berglund, Bengt Jarvholm, Nicholas E. Day, Timothy J. Key, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli, Shelia Bingham, Paolo Vineis

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse, statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P=0.02), vitamin E (P=0.04) and alcohol (P=0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P=0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances.

Original languageEnglish
Pages (from-to)489-495
Number of pages7
JournalBritish Journal of Nutrition
Volume100
Issue number3
DOIs
Publication statusPublished - 2008

Fingerprint

DNA Adducts
Prospective Studies
Diet
Food
Neoplasms
Mutagens
Carcinogens
Fruit
Biomarkers
Nitrosamines
Aflatoxins
Polycyclic Aromatic Hydrocarbons
Dietary Fiber
Feeding Behavior
4-aminobiphenyl-hemoglobin
Vitamin E
Amines
Gastrointestinal Tract
Colon
Leukocytes

Keywords

  • Air pollution
  • DNA adducts
  • Fibre intake
  • Haemoglobin adducts
  • Non-smokers

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study. / Peluso, Marco; Airoldi, Luisa; Munnia, Armelle; Colombi, Alessandro; Veglia, Fabrizio; Autrup, Herman; Dunning, Alison; Garte, Seymour; Gormally, Emmanuelle; Malaveille, Christian; Matullo, Giuseppe; Overvad, Kim; Raaschou-Nielsen, Ole; Clavel-Chapelon, Francoise; Linseisen, Jacob; Boeing, Heiner; Trichopoulou, Antonia; Palli, Domenico; Krogh, Vittorio; Tumino, Rosario; Panico, Salvatore; Bueno-De-Mesquita, Bas H.; Peeters, Petra H.; Kumle, Merethe; Agudo, Antonio; Martinez, Carmen; Dorronsoro, Miren; Barricarte, Aurelio; Tormo, María Jose; Quiros, José Ramón; Berglund, Goran; Jarvholm, Bengt; Day, Nicholas E.; Key, Timothy J.; Saracci, Rodolfo; Kaaks, Rudolf; Riboli, Elio; Bingham, Shelia; Vineis, Paolo.

In: British Journal of Nutrition, Vol. 100, No. 3, 2008, p. 489-495.

Research output: Contribution to journalArticle

Peluso, M, Airoldi, L, Munnia, A, Colombi, A, Veglia, F, Autrup, H, Dunning, A, Garte, S, Gormally, E, Malaveille, C, Matullo, G, Overvad, K, Raaschou-Nielsen, O, Clavel-Chapelon, F, Linseisen, J, Boeing, H, Trichopoulou, A, Palli, D, Krogh, V, Tumino, R, Panico, S, Bueno-De-Mesquita, BH, Peeters, PH, Kumle, M, Agudo, A, Martinez, C, Dorronsoro, M, Barricarte, A, Tormo, MJ, Quiros, JR, Berglund, G, Jarvholm, B, Day, NE, Key, TJ, Saracci, R, Kaaks, R, Riboli, E, Bingham, S & Vineis, P 2008, 'Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study', British Journal of Nutrition, vol. 100, no. 3, pp. 489-495. https://doi.org/10.1017/S0007114508911600
Peluso, Marco ; Airoldi, Luisa ; Munnia, Armelle ; Colombi, Alessandro ; Veglia, Fabrizio ; Autrup, Herman ; Dunning, Alison ; Garte, Seymour ; Gormally, Emmanuelle ; Malaveille, Christian ; Matullo, Giuseppe ; Overvad, Kim ; Raaschou-Nielsen, Ole ; Clavel-Chapelon, Francoise ; Linseisen, Jacob ; Boeing, Heiner ; Trichopoulou, Antonia ; Palli, Domenico ; Krogh, Vittorio ; Tumino, Rosario ; Panico, Salvatore ; Bueno-De-Mesquita, Bas H. ; Peeters, Petra H. ; Kumle, Merethe ; Agudo, Antonio ; Martinez, Carmen ; Dorronsoro, Miren ; Barricarte, Aurelio ; Tormo, María Jose ; Quiros, José Ramón ; Berglund, Goran ; Jarvholm, Bengt ; Day, Nicholas E. ; Key, Timothy J. ; Saracci, Rodolfo ; Kaaks, Rudolf ; Riboli, Elio ; Bingham, Shelia ; Vineis, Paolo. / Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study. In: British Journal of Nutrition. 2008 ; Vol. 100, No. 3. pp. 489-495.
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AU - Peluso, Marco

AU - Airoldi, Luisa

AU - Munnia, Armelle

AU - Colombi, Alessandro

AU - Veglia, Fabrizio

AU - Autrup, Herman

AU - Dunning, Alison

AU - Garte, Seymour

AU - Gormally, Emmanuelle

AU - Malaveille, Christian

AU - Matullo, Giuseppe

AU - Overvad, Kim

AU - Raaschou-Nielsen, Ole

AU - Clavel-Chapelon, Francoise

AU - Linseisen, Jacob

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Palli, Domenico

AU - Krogh, Vittorio

AU - Tumino, Rosario

AU - Panico, Salvatore

AU - Bueno-De-Mesquita, Bas H.

AU - Peeters, Petra H.

AU - Kumle, Merethe

AU - Agudo, Antonio

AU - Martinez, Carmen

AU - Dorronsoro, Miren

AU - Barricarte, Aurelio

AU - Tormo, María Jose

AU - Quiros, José Ramón

AU - Berglund, Goran

AU - Jarvholm, Bengt

AU - Day, Nicholas E.

AU - Key, Timothy J.

AU - Saracci, Rodolfo

AU - Kaaks, Rudolf

AU - Riboli, Elio

AU - Bingham, Shelia

AU - Vineis, Paolo

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KW - DNA adducts

KW - Fibre intake

KW - Haemoglobin adducts

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