Bullous Pemphigoid: Physiopathology, Clinical Features and Management

Giovanni Di Zenzo, Gionata Marazza, Luca Borradori

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

There has been a considerable progress in the understanding of the physiopathology of BP during the past 2 decades. The insights into the humoral and cellular immune response against BP180 and BP230 have increased significantly. Nevertheless, the factors underlying the initiation of the disease leading to a disruption of self-tolerance remain unclear. Clinically, the disease shows protean presentations, and diagnostic delay is common. A practical, relevant, and unresolved question is how to identify patients suffering from BP at an early stage of the disease, when direct immunofluorescence microscopy findings still may be negative. The characterization of markers allowing the differentiation of BP from other pruritic eruptions occurring in the elderly population would be extremely helpful in daily practice. Finally, despite the knowledge that potent topical steroids are efficient in controlling the disease, management of BP sometimes remains difficult and requires systemic therapies. It is hoped that a better knowledge of the regulation of the autoimmune response in BP also will facilitate the design of novel immunomodulatory therapeutic approaches devoid of the severe side effects of current immunosuppressive treatments.

Original languageEnglish
Pages (from-to)257-288
Number of pages32
JournalAdvances in Dermatology
Volume23
DOIs
Publication statusPublished - 2007

Fingerprint

Bullous Pemphigoid
Self Tolerance
Direct Fluorescent Antibody Technique
Peptide Initiation Factors
Differentiation Antigens
Immunosuppressive Agents
Humoral Immunity
Disease Management
Autoimmunity
Fluorescence Microscopy
Cellular Immunity
Therapeutics
Steroids
Population

ASJC Scopus subject areas

  • Dermatology

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Bullous Pemphigoid : Physiopathology, Clinical Features and Management. / Di Zenzo, Giovanni; Marazza, Gionata; Borradori, Luca.

In: Advances in Dermatology, Vol. 23, 2007, p. 257-288.

Research output: Contribution to journalArticle

Di Zenzo, Giovanni ; Marazza, Gionata ; Borradori, Luca. / Bullous Pemphigoid : Physiopathology, Clinical Features and Management. In: Advances in Dermatology. 2007 ; Vol. 23. pp. 257-288.
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