Bullous pemphigoid: Trigger and predisposing factors

Francesco Moro, Luca Fania, Jo Linda Maria Sinagra, Adele Salemme, Giovanni Di Zenzo

Research output: Contribution to journalReview articlepeer-review

Abstract

Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or electrical burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, chemical preparations, transplants, and infections may induce or exacerbate BP disease. Identification of predisposing and trigger factors can increase the understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on the recognition of a possible trigger factor can improve prognosis by promptly removing it.

Original languageEnglish
Article number1432
Pages (from-to)1-29
Number of pages29
JournalBiomolecules
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Autoimmune bullous disease
  • Bullous pemphigoid
  • Etiopathogenesis
  • Predisposing factors
  • Trigger factors

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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