Burden of paediatric influenza in Western Europe: A systematic review

Evgeniya N. Antonova, Catherine E. Rycroft, Christopher S. Ambrose, Terho Heikkinen, Nicola Principi

Research output: Contribution to journalArticle

Abstract

Background: Influenza illness in children causes significant clinical and economic burden. Although some European countries have adopted influenza immunisation policies for healthy children, the debate about paediatric influenza vaccination in most countries of the European Union is ongoing. Our aim was to summarise influenza burden (in terms of health outcomes and economic burden) in children in Western Europe via a systematic literature review. Methods. We conducted a systematic literature search of PubMed, EMBASE, and the Cochrane Library (1970-April 2011) and extracted data on influenza burden in children (defined as aged ≤ 18 years) from 50 publications (13 reporting laboratory-confirmed influenza; 37 reporting influenza-like illness). Results: Children with laboratory-confirmed influenza experienced hospitalisations (0.3%-20%), medical visits (1.7-2.8 visits per case), antibiotic prescriptions (7%-55%), and antipyretic or other medications for symptomatic relief (76%-99%); young children and those with severe illness had the highest rates of health care use. Influenza in children also led to absenteeism from day care, school, or work for the children, their siblings, and their parents. Average (mean or median) length of absence from school or day care associated with confirmed influenza ranged from 2.8 to 12.0 days for the children, from 1.3 to 6.0 days for their siblings, and from 1.3 to 6.3 days for their parents. Influenza negatively affected health-related quality of life in children with asthma, including symptoms and activities; this negative effect was smaller in vaccinated children than in non-vaccinated children. Conclusions: Influenza burden in children is substantial and has a significant direct impact on the ill children and an indirect impact on their siblings and parents. The identified evidence regarding the burden of influenza may help inform both influenza antiviral use in children and paediatric immunisation policies in European countries.

Original languageEnglish
Article number968
JournalBMC Public Health
Volume12
Issue number1
DOIs
Publication statusPublished - 2012

Fingerprint

Human Influenza
Pediatrics
Siblings
Parents
Immunization
Economics
Absenteeism
Antipyretics
European Union
PubMed
Libraries
Antiviral Agents
Prescriptions
Publications
Vaccination
Hospitalization
Asthma
Quality of Life

Keywords

  • Burden
  • Children
  • Europe
  • Influenza
  • Vaccination

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Antonova, E. N., Rycroft, C. E., Ambrose, C. S., Heikkinen, T., & Principi, N. (2012). Burden of paediatric influenza in Western Europe: A systematic review. BMC Public Health, 12(1), [968]. https://doi.org/10.1186/1471-2458-12-968

Burden of paediatric influenza in Western Europe : A systematic review. / Antonova, Evgeniya N.; Rycroft, Catherine E.; Ambrose, Christopher S.; Heikkinen, Terho; Principi, Nicola.

In: BMC Public Health, Vol. 12, No. 1, 968, 2012.

Research output: Contribution to journalArticle

Antonova, EN, Rycroft, CE, Ambrose, CS, Heikkinen, T & Principi, N 2012, 'Burden of paediatric influenza in Western Europe: A systematic review', BMC Public Health, vol. 12, no. 1, 968. https://doi.org/10.1186/1471-2458-12-968
Antonova, Evgeniya N. ; Rycroft, Catherine E. ; Ambrose, Christopher S. ; Heikkinen, Terho ; Principi, Nicola. / Burden of paediatric influenza in Western Europe : A systematic review. In: BMC Public Health. 2012 ; Vol. 12, No. 1.
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