Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase

Maitham Husain, Eyal Grunebaum, Ahmed Naqvi, Adelle Atkinson, Bo Y. Ngan, Alessandro Aiuti, Chaim M. Roifman

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalJournal of Pediatrics
Volume151
Issue number1
DOIs
Publication statusPublished - Jul 2007

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Severe Combined Immunodeficiency
Adenosine Deaminase
Burkitt Lymphoma
Cellular Immunity
Severe combined immunodeficiency due to adenosine deaminase deficiency
Therapeutics

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase. / Husain, Maitham; Grunebaum, Eyal; Naqvi, Ahmed; Atkinson, Adelle; Ngan, Bo Y.; Aiuti, Alessandro; Roifman, Chaim M.

In: Journal of Pediatrics, Vol. 151, No. 1, 07.2007, p. 93-95.

Research output: Contribution to journalArticle

Husain, Maitham ; Grunebaum, Eyal ; Naqvi, Ahmed ; Atkinson, Adelle ; Ngan, Bo Y. ; Aiuti, Alessandro ; Roifman, Chaim M. / Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase. In: Journal of Pediatrics. 2007 ; Vol. 151, No. 1. pp. 93-95.
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