Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase

Maitham Husain; Eyal Grunebaum; Ahmed Naqvi; Adelle Atkinson; Bo Y. Ngan; Alessandro Aiuti; Chaim M. Roifman

doi:10.1016/j.jpeds.2007.03.059

Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase

Maitham Husain, Eyal Grunebaum, Ahmed Naqvi, Adelle Atkinson, Bo Y. Ngan, Alessandro Aiuti, Chaim M. Roifman

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.

Original language	English
Pages (from-to)	93-95
Number of pages	3
Journal	Journal of Pediatrics
Volume	151
Issue number	1
DOIs	https://doi.org/10.1016/j.jpeds.2007.03.059
Publication status	Published - Jul 2007

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1016/j.jpeds.2007.03.059

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title = "Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase",

abstract = "We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.",

author = "Maitham Husain and Eyal Grunebaum and Ahmed Naqvi and Adelle Atkinson and Ngan, {Bo Y.} and Alessandro Aiuti and Roifman, {Chaim M.}",

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AU - Husain, Maitham

AU - Grunebaum, Eyal

AU - Naqvi, Ahmed

AU - Atkinson, Adelle

AU - Ngan, Bo Y.

AU - Aiuti, Alessandro

AU - Roifman, Chaim M.

PY - 2007/7

Y1 - 2007/7

N2 - We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.

AB - We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.

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Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase

Abstract

ASJC Scopus subject areas

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