Burkitt's Lymphoma in a Patient with Adenosine Deaminase Deficiency-Severe Combined Immunodeficiency Treated with Polyethylene Glycol-Adenosine Deaminase

Maitham Husain, Eyal Grunebaum, Ahmed Naqvi, Adelle Atkinson, Bo Y. Ngan, Alessandro Aiuti, Chaim M. Roifman

Research output: Contribution to journalArticle

Abstract

We describe a patient with severe combined immunodeficiency because of aberrations in adenosine deaminase (ADA) who despite adequate replacement with polyethylene glycol-linked ADA (PEG-ADA) for 13 years developed Burkitt's lymphoma. Although treatment corrected the metabolic abnormalities caused by ADA deficiency, it failed to fully restore cellular immunity.

Original languageEnglish
Pages (from-to)93-95
Number of pages3
JournalJournal of Pediatrics
Volume151
Issue number1
DOIs
Publication statusPublished - Jul 2007

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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