Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function.

C. Eftimiadi, S. Valente, S. Mangiante, M. Ferrarini

Research output: Contribution to journalArticlepeer-review

Abstract

The effect on B-lymphocytes of butyric acid, a metabolic by-product formed by selected anaerobic bacteria of the subgingival plaque and present in mM amounts in the crevicular fluid of patients affected by adult periodontitis was investigated. A dose-dependent inhibition of both mitogenesis and Ig production in B-cells challenged with formalinized Staphylococcus aureus, strain Cowan I (SAC), was observed. A role of this molecule in the downregulation of the local immune response in periodontal patients is proposed.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalMinerva Stomatologica
Volume44
Issue number10
Publication statusPublished - Oct 1995

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