Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function.

C. Eftimiadi, S. Valente, S. Mangiante, M. Ferrarini

Research output: Contribution to journalArticle

Abstract

The effect on B-lymphocytes of butyric acid, a metabolic by-product formed by selected anaerobic bacteria of the subgingival plaque and present in mM amounts in the crevicular fluid of patients affected by adult periodontitis was investigated. A dose-dependent inhibition of both mitogenesis and Ig production in B-cells challenged with formalinized Staphylococcus aureus, strain Cowan I (SAC), was observed. A role of this molecule in the downregulation of the local immune response in periodontal patients is proposed.

Original languageEnglish
Pages (from-to)445-447
Number of pages3
JournalMinerva Stomatologica
Volume44
Issue number10
Publication statusPublished - Oct 1995

Fingerprint Dive into the research topics of 'Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function.'. Together they form a unique fingerprint.

  • Cite this

    Eftimiadi, C., Valente, S., Mangiante, S., & Ferrarini, M. (1995). Butyric acid, a metabolic end product of anaerobic bacteria, inhibits B-lymphocyte function. Minerva Stomatologica, 44(10), 445-447.