Butyric acid

pharmacological aspects and routes of administration

L. Spina, F. Cavallaro, N. I. Fardowza, P. Lagoussis, D. Bona, C. Ciscato, A. Rigante, M. Vecchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Butyric acid is an organic acid containing 4 carbon atoms and is produced in the large intestine through fermentation by the intestinal bacterial flora of undigested sugars and dietary fibre. It is considered the most important source of energy for colonic cells; in addition, it exerts numerous anti-inflammatory effects while regulating proliferation of colonocytes and absorption of water and electrolytes. Many intestinal diseases are characterised by reduced concentrations of butyric acid in the colon and drugs that successfully prevent oxidation have been shown to be effective in the treatment of chronic inflammatory intestinal diseases.

Original languageEnglish
Pages (from-to)7-11
Number of pages5
JournalDigestive and Liver Disease Supplements
Volume1
Issue number1
DOIs
Publication statusPublished - Sep 2007

Fingerprint

Intestinal Diseases
Butyric Acid
Pharmacology
Large Intestine
Dietary Fiber
Electrolytes
Fermentation
Colon
Anti-Inflammatory Agents
Carbon
Acids
Water
Pharmaceutical Preparations
Gastrointestinal Microbiome

Keywords

  • Butyric acid
  • Colon
  • Inflammation

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Butyric acid : pharmacological aspects and routes of administration. / Spina, L.; Cavallaro, F.; Fardowza, N. I.; Lagoussis, P.; Bona, D.; Ciscato, C.; Rigante, A.; Vecchi, M.

In: Digestive and Liver Disease Supplements, Vol. 1, No. 1, 09.2007, p. 7-11.

Research output: Contribution to journalArticle

Spina, L, Cavallaro, F, Fardowza, NI, Lagoussis, P, Bona, D, Ciscato, C, Rigante, A & Vecchi, M 2007, 'Butyric acid: pharmacological aspects and routes of administration', Digestive and Liver Disease Supplements, vol. 1, no. 1, pp. 7-11. https://doi.org/10.1016/S1594-5804(08)60004-2
Spina, L. ; Cavallaro, F. ; Fardowza, N. I. ; Lagoussis, P. ; Bona, D. ; Ciscato, C. ; Rigante, A. ; Vecchi, M. / Butyric acid : pharmacological aspects and routes of administration. In: Digestive and Liver Disease Supplements. 2007 ; Vol. 1, No. 1. pp. 7-11.
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