C-11 choline versus F-18 fluorodeoxyglucose for imaging meningiomas: An initial experience

Giampiero Giovacchini, Federico Fallanca, Claudio Landoni, Luigi Gianolli, Piero Picozzi, Luca Attuati, Mariarosa Terreni, Maria Picchio, Cristina Messa, Ferruccio Fazio

Research output: Contribution to journalArticlepeer-review


Purpose:Positron emission tomography/computed tomography (PET/CT) with C-11 choline has been used for staging, restaging, and follow-up of various tumors, whereas its role for imaging meningiomas has only been preliminarily explored. The aim of this study was to compare C-11 choline and F-18 fluorodeoxyglucose (F-18 FDG) uptake in meningiomas and relate these findings to the histopathological analysis. Methods: Two sequential three-dimensional PET/CT scans with 370 MBq (10 mCi) of C-11 choline and 370 MBq (10 mCi) of F-18 FDG were performed 2 hours apart in 7 patients with histologically confirmed meningiomas. Five patients had WHO grade I and 2 had WHO grade II meningioma. For each scan, two-dimensional regions of interest were drawn on tumor boundaries and on the contralateral side on CT images and copied to the corresponding PET images. SUVmax and tumor-to-background ratio were calculated. Results: Relative to the contralateral side, C-11 choline uptake was increased in all meningiomas, whereas F-18 FDG uptake was decreased in 6 patients and increased in 1 of the 2 patients with grade II meningiomas. In the whole group, SUVmax of C-11 choline and F-18 FDG were 3.6 ± 1.3 and 5.7 ± 1.3, respectively. The tumor-to-background ratio for C-11 choline was much higher than that for F-18 FDG (5.3 ± 0.8 vs. 0.9 ± 0.2, respectively) (P <0.001). The uptake of C-11 choline was higher in patients with grade II than in grade I meningiomas. Conclusions:These preliminary results suggest that C-11 choline may better image meningiomas in comparison with F-18 FDG. Clinical applications of C-11 choline PET/CT for grading and follow-up of meningiomas need to be assessed in further studies.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalClinical Nuclear Medicine
Issue number1
Publication statusPublished - Jan 2009


  • C-11 choline
  • F-18 FDG
  • Meningiomas
  • PET/CT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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