C and CX3C chemokines: Cell sources and physiopathological implications

Laura Stievano, Erich Piovan, Alberto Amadori

Research output: Contribution to journalArticle

Abstract

Within the fascinating world of chemokines, C and CX3C chemokines have long been regarded as two minor components, even though they present unique features and show less redundancy than the other chemokine families. Nevertheless, the body of data on their expression and role in various inflammatory disorders has grown in the past few years. The C chemokine family is represented by two chemokines, XCL1/lymphotactin-α and XCL2/lymphotactin-β, whereas the CX3C chemokine family contains only one member, called CX3CL1/ fractalkine. In this review, we present an overview on the structure, expression and signaling properties of these chemokines and their respective receptors and examine how they contribute to inflammation and the regulation of leukocyte trafficking, as well as their potential role in the pathophysiology of human inflammatory diseases. Taken together, these data expand the biological importance of C and CX3C chemokines from that of simple immune modulators to a much broader biological role, even though their precise commitment within the framework of immune responses has still to be determined.

Original languageEnglish
Pages (from-to)205-228
Number of pages24
JournalCritical Reviews in Immunology
Volume24
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

CX3C Chemokines
C Chemokines
Chemokines
Chemokine CX3CL1
Leukocytes
Inflammation

Keywords

  • Chemokines
  • CXCL1
  • Inflammation
  • Leukocytes
  • Tumor immunology
  • XCL1

ASJC Scopus subject areas

  • Immunology

Cite this

C and CX3C chemokines : Cell sources and physiopathological implications. / Stievano, Laura; Piovan, Erich; Amadori, Alberto.

In: Critical Reviews in Immunology, Vol. 24, No. 3, 2004, p. 205-228.

Research output: Contribution to journalArticle

@article{dcdcc7dddd154931ada8bf0f543fdee9,
title = "C and CX3C chemokines: Cell sources and physiopathological implications",
abstract = "Within the fascinating world of chemokines, C and CX3C chemokines have long been regarded as two minor components, even though they present unique features and show less redundancy than the other chemokine families. Nevertheless, the body of data on their expression and role in various inflammatory disorders has grown in the past few years. The C chemokine family is represented by two chemokines, XCL1/lymphotactin-α and XCL2/lymphotactin-β, whereas the CX3C chemokine family contains only one member, called CX3CL1/ fractalkine. In this review, we present an overview on the structure, expression and signaling properties of these chemokines and their respective receptors and examine how they contribute to inflammation and the regulation of leukocyte trafficking, as well as their potential role in the pathophysiology of human inflammatory diseases. Taken together, these data expand the biological importance of C and CX3C chemokines from that of simple immune modulators to a much broader biological role, even though their precise commitment within the framework of immune responses has still to be determined.",
keywords = "Chemokines, CXCL1, Inflammation, Leukocytes, Tumor immunology, XCL1",
author = "Laura Stievano and Erich Piovan and Alberto Amadori",
year = "2004",
doi = "10.1615/CritRevImmunol.v24.i3.40",
language = "English",
volume = "24",
pages = "205--228",
journal = "Critical Reviews in Immunology",
issn = "1040-8401",
publisher = "Begell House Inc.",
number = "3",

}

TY - JOUR

T1 - C and CX3C chemokines

T2 - Cell sources and physiopathological implications

AU - Stievano, Laura

AU - Piovan, Erich

AU - Amadori, Alberto

PY - 2004

Y1 - 2004

N2 - Within the fascinating world of chemokines, C and CX3C chemokines have long been regarded as two minor components, even though they present unique features and show less redundancy than the other chemokine families. Nevertheless, the body of data on their expression and role in various inflammatory disorders has grown in the past few years. The C chemokine family is represented by two chemokines, XCL1/lymphotactin-α and XCL2/lymphotactin-β, whereas the CX3C chemokine family contains only one member, called CX3CL1/ fractalkine. In this review, we present an overview on the structure, expression and signaling properties of these chemokines and their respective receptors and examine how they contribute to inflammation and the regulation of leukocyte trafficking, as well as their potential role in the pathophysiology of human inflammatory diseases. Taken together, these data expand the biological importance of C and CX3C chemokines from that of simple immune modulators to a much broader biological role, even though their precise commitment within the framework of immune responses has still to be determined.

AB - Within the fascinating world of chemokines, C and CX3C chemokines have long been regarded as two minor components, even though they present unique features and show less redundancy than the other chemokine families. Nevertheless, the body of data on their expression and role in various inflammatory disorders has grown in the past few years. The C chemokine family is represented by two chemokines, XCL1/lymphotactin-α and XCL2/lymphotactin-β, whereas the CX3C chemokine family contains only one member, called CX3CL1/ fractalkine. In this review, we present an overview on the structure, expression and signaling properties of these chemokines and their respective receptors and examine how they contribute to inflammation and the regulation of leukocyte trafficking, as well as their potential role in the pathophysiology of human inflammatory diseases. Taken together, these data expand the biological importance of C and CX3C chemokines from that of simple immune modulators to a much broader biological role, even though their precise commitment within the framework of immune responses has still to be determined.

KW - Chemokines

KW - CXCL1

KW - Inflammation

KW - Leukocytes

KW - Tumor immunology

KW - XCL1

UR - http://www.scopus.com/inward/record.url?scp=7044227965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=7044227965&partnerID=8YFLogxK

U2 - 10.1615/CritRevImmunol.v24.i3.40

DO - 10.1615/CritRevImmunol.v24.i3.40

M3 - Article

C2 - 15482255

AN - SCOPUS:7044227965

VL - 24

SP - 205

EP - 228

JO - Critical Reviews in Immunology

JF - Critical Reviews in Immunology

SN - 1040-8401

IS - 3

ER -