C-C Chemokines, IL-16, and Soluble Antiviral Factor Activity Are Increased in Cloned T Cells from Subjects with Long-Term Nonprogressive HIV Infection

Enrico Scala, Gianpiero D'Offizi, Rosamaria Rosso, Ombretta Turriziani, Rosetta Ferrara, Anna Maria Mazzone, Guido Antonelli, Fernando Aiuti, Roberto Paganelli

Research output: Contribution to journalArticlepeer-review

Abstract

A combination of three β, or C-C, chemokines, as well as IL-16, have been shown to inhibit HIV replication in vitro. Cellular antiviral factor is a more potent agent, and acts on all HIV strains. All are mainly, but not exclusively, produced by CD8+ T cells, both in HIV+ and healthy subjects. We studied the production of these HIV-suppressive factors in patients with HIV infection at different stages of disease. No difference in production by PBMC stimulated with PHA has been observed in asymptomatic HIV+, long-term nonprogressors (LTnP), and AIDS patients. When T cell line supernatants from these three groups were studied, no significant difference was found for C-C chemokines or IL-16 production, and viral suppression. However, T cell clones from LTnP secreted higher levels of all three chemokines, IL-16, and exerted a stronger inhibition on HIV replication. CD8+ clones showed a higher production than CD4+ clones. These clones were able to produce all antiviral factors irrespective of the secretion of type 1 or type 2 cytokines. The antiviral activities were not correlated, implying that viral suppression did not depend solely on C-C chemokines or IL-16. We postulate that all factors are needed to prevent HIV disease progression.

Original languageEnglish
Pages (from-to)4485-4492
Number of pages8
JournalJournal of Immunology
Volume158
Issue number9
Publication statusPublished - May 1 1997

ASJC Scopus subject areas

  • Immunology

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