C-Cbl targets active Src for autophagy

Research output: Contribution to journalArticle

Abstract

Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src.

Original languageEnglish
Pages (from-to)48-49
Number of pages2
JournalNature Cell Biology
Volume14
Issue number1
DOIs
Publication statusPublished - Jan 2012

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Autophagy
Cell Survival
Ubiquitin-Protein Ligases
src-Family Kinases
Neoplasms
Cell Death
Autophagosomes

ASJC Scopus subject areas

  • Cell Biology

Cite this

C-Cbl targets active Src for autophagy. / Cecconi, Francesco.

In: Nature Cell Biology, Vol. 14, No. 1, 01.2012, p. 48-49.

Research output: Contribution to journalArticle

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