C-Cbl targets active Src for autophagy

Research output: Contribution to journalArticlepeer-review


Autophagy can promote both cancer cell survival and death, and the mechanisms by which it mediates these disparate processes are under intense investigation. Autophagosomes are now shown to entrap and promote degradation of the active tyrosine kinase Src, enabling tumour cell survival. The E3 ubiquitin ligase c-Cbl acts as an autophagosome cargo receptor for Src.

Original languageEnglish
Pages (from-to)48-49
Number of pages2
JournalNature Cell Biology
Issue number1
Publication statusPublished - Jan 2012

ASJC Scopus subject areas

  • Cell Biology


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