c-erbB-2 protein in serum of primary lung cancer patients

Rosa Filiberti, Paola Marroni, Michela Paganuzzi, Valeria Izzo, Paola Padovani, Mara Cafferata, Andrea Ardizzoni, Monica Neri, Luigi Raimondi, Riccardo Puntoni

Research output: Contribution to journalArticlepeer-review

Abstract

We determined c-erbB-2 protein level in serum of 86 primary lung cancer patients (78 non-small cell lung carcinomas (NSCLC), 3 small cell carcinomas, 5 not histologically defined) and in 61 controls. Aim of this study was to evaluate the clinical usefulness of c-erbB-2 as marker for lung cancer diagnosis. The protein was measured with a commercially available sandwich enzyme immunoassay. Mean levels of c-erbB-2 were 72.8 ± 122.3 fmol/ml in lung cancers and 64.6 ± 17.5 fmol/ml in controls (P = 0.2). No association was found between c-erbB-2 levels and histotype, tumor stage, sex and smoking habits. Among NSCLC, only four patients showed a c-erbB-2 concentration higher than the selected cut-off value of 99.6 fmol/ml. Subjects with levels higher than the 75th percentile in tumors (73 fmol/ml) had a shorter median survival than those with lower levels (6.3 months versus 10.0 months, P = 0.003). Our results indicated that serum c-erbB-2 protein is not a reliable diagnostic marker. There is, however, a suggestion of a possible clinical usefulness in terms of survival prediction.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalCancer Detection and Prevention
Volume26
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • c-erbB-2
  • Lung cancer
  • Oncoprotein
  • Tumor marker

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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