c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions

M. G. Lampugnani; N. Polentarutti; M. Pedenovi; A. Mantovani; E. Dejana; F. Colotta

doi:10.1016/0014-4827(90)90320-A

c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions

M. G. Lampugnani, N. Polentarutti, M. Pedenovi, A. Mantovani, E. Dejana, F. Colotta

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.

Original language	English
Pages (from-to)	381-384
Number of pages	4
Journal	Experimental Cell Research
Volume	186
Issue number	2
DOIs	https://doi.org/10.1016/0014-4827(90)90320-A
Publication status	Published - 1990

ASJC Scopus subject areas

Cell Biology

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title = "c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions",

abstract = "Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.",

author = "Lampugnani, {M. G.} and N. Polentarutti and M. Pedenovi and A. Mantovani and E. Dejana and F. Colotta",

year = "1990",

doi = "10.1016/0014-4827(90)90320-A",

language = "English",

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T1 - c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions

AU - Lampugnani, M. G.

AU - Polentarutti, N.

AU - Pedenovi, M.

AU - Mantovani, A.

AU - Dejana, E.

AU - Colotta, F.

PY - 1990

Y1 - 1990

N2 - Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.

AB - Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.

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c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions

Abstract

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