c-fos and c-myc Expression in human endothelial cells as a function of different culture conditions

M. G. Lampugnani, N. Polentarutti, M. Pedenovi, A. Mantovani, E. Dejana, F. Colotta

Research output: Contribution to journalArticlepeer-review

Abstract

Cultured human umbilical vein endothelial cells (HEC) could be induced to express c-fos and c-myc mRNA by either serum or ECGS (endothelial cell growth supplement). Neither agonist separately could support HEC proliferation but the combination did. Expression of c-fos and c-myc mRNA in the presence of both serum and ECGS was similar to that observed after each of the two stimuli was introduced separately. c-fos and c-myc expression in cultured HEC, even if related, is not necessarily accompanied by stimulation of cell growth.

Original languageEnglish
Pages (from-to)381-384
Number of pages4
JournalExperimental Cell Research
Volume186
Issue number2
DOIs
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Cell Biology

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