C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation

G. Bosco, A. Casabona, G. Giaquinta, T. Maci, M. S. Valle, V. Perciavalle

Research output: Contribution to journalArticle

Abstract

The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalArchives Italiennes de Biologie
Volume138
Issue number3
Publication statusPublished - Jul 2000

Fingerprint

Kainic Acid Receptors
Cerebellar Nuclei
AMPA Receptors
Dizocilpine Maleate
N-Methyl-D-Aspartate Receptors
Neurons
Injections
GYKI 52466

ASJC Scopus subject areas

  • Medicine(all)

Cite this

C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation. / Bosco, G.; Casabona, A.; Giaquinta, G.; Maci, T.; Valle, M. S.; Perciavalle, V.

In: Archives Italiennes de Biologie, Vol. 138, No. 3, 07.2000, p. 229-240.

Research output: Contribution to journalArticle

Bosco, G, Casabona, A, Giaquinta, G, Maci, T, Valle, MS & Perciavalle, V 2000, 'C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation', Archives Italiennes de Biologie, vol. 138, no. 3, pp. 229-240.
Bosco, G. ; Casabona, A. ; Giaquinta, G. ; Maci, T. ; Valle, M. S. ; Perciavalle, V. / C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation. In: Archives Italiennes de Biologie. 2000 ; Vol. 138, No. 3. pp. 229-240.
@article{f4bc088a018c40229e5e5956794b321d,
title = "C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation",
abstract = "The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.",
author = "G. Bosco and A. Casabona and G. Giaquinta and T. Maci and Valle, {M. S.} and V. Perciavalle",
year = "2000",
month = "7",
language = "English",
volume = "138",
pages = "229--240",
journal = "Archives Italiennes de Biologie",
issn = "0003-9829",
publisher = "Pisa University Press",
number = "3",

}

TY - JOUR

T1 - C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation

AU - Bosco, G.

AU - Casabona, A.

AU - Giaquinta, G.

AU - Maci, T.

AU - Valle, M. S.

AU - Perciavalle, V.

PY - 2000/7

Y1 - 2000/7

N2 - The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.

AB - The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.

UR - http://www.scopus.com/inward/record.url?scp=0033921040&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033921040&partnerID=8YFLogxK

M3 - Article

C2 - 10951896

AN - SCOPUS:0033921040

VL - 138

SP - 229

EP - 240

JO - Archives Italiennes de Biologie

JF - Archives Italiennes de Biologie

SN - 0003-9829

IS - 3

ER -