Abstract
The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.
| Original language | English |
|---|---|
| Pages (from-to) | 229-240 |
| Number of pages | 12 |
| Journal | Archives Italiennes de Biologie |
| Volume | 138 |
| Issue number | 3 |
| Publication status | Published - Jul 2000 |
Fingerprint
ASJC Scopus subject areas
- Medicine(all)
Cite this
C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation. / Bosco, G.; Casabona, A.; Giaquinta, G.; Maci, T.; Valle, M. S.; Perciavalle, V.
In: Archives Italiennes de Biologie, Vol. 138, No. 3, 07.2000, p. 229-240.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - C-Fos expression in the basilar pontine nuclei and reticulotegmental nucleus of the rat following lateral cerebellar nucleus stimulation
AU - Bosco, G.
AU - Casabona, A.
AU - Giaquinta, G.
AU - Maci, T.
AU - Valle, M. S.
AU - Perciavalle, V.
PY - 2000/7
Y1 - 2000/7
N2 - The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.
AB - The present study was carried out with the aim to observe whether, in the rat, the electric activation of the projection form the cerebellar lateral nucleus (LN) to the basilar pontine nuclei (BPN) and to the reticulotegmental nucleus (RtTG) is capable to induce the c-Fos expression. In particular, we compared the effects of a continuous LN stimulation at low- frequency (tonic stimulation) with those induced by high frequency pulse trains (phasic stimulation). The observed results show that the stimulation of LN induces c-Fos expression in a significant fraction of neurons in the contralateral BPN and RtTG. It was also observed that phasic stimulation was slightly more capable in producing c-Fos expression with respect to the tonic stimulation. Furthermore, systemic injection of MK-801, a non-competitive antagonist of the NMDA receptor, reduced the LN-induced c-Fos expression in BPN and RtTG. In contrast, GYKI 52466, an AMPA/kainate receptor antagonist, did not change the LN driven induction of c-Fos in both BPN and RtTG.
UR - http://www.scopus.com/inward/record.url?scp=0033921040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033921040&partnerID=8YFLogxK
M3 - Article
C2 - 10951896
AN - SCOPUS:0033921040
VL - 138
SP - 229
EP - 240
JO - Archives Italiennes de Biologie
JF - Archives Italiennes de Biologie
SN - 0003-9829
IS - 3
ER -