c-fos Proto-oncogene expression in human NK-LGL cells: Expression is not constitutive and is associated with functional activation

F. Colotta, N. Polentarutti, A. Pirelli, M. Dibello, P. Allavena, A. Mantovani

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Abstract

Unlike mature myeloid and monocytic cells and cell lines committed to terminal myelomonocytic differentiation, highly purified preparation of human natural killer cells/large granular lymphocytes (NK/LGL) did not spontaneously express the c-fos proto-oncogene. Transient expression of c-fos in NK-LGL was associated with functional activation with IL-2, IFN-γ, LPS and PMA, which increased their cytotoxic activity, lymphokine secretion and in vitro chemotaxis. These results, together with the finding that T-cell receptor genes are in germ-line configuration in the vast majority of peripheral blood NK/LGL, are compatible with the hypothesis that these cells represent a separate hematopoietic lineage.

Original languageEnglish
Pages (from-to)709-711
Number of pages3
JournalInternational Journal of Cancer
Volume42
Issue number5
Publication statusPublished - 1988

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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